Trilaurin
Based on 1 Customer Validation
Trilaurin is an orally active triglyceride. Trilaurin inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice. Trilaurin increases plasma high-density lipoprotein cholesterol and apolipoprotein A-I concentrations. Trilaurin is used as an occlusive skin conditioning agent and/or non-aqueous thickener in cosmetics.
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- Purity: 99.78%
- CAS No.: 538-24-9
- 화학식: C39H74O6
- 분자량:639.00
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Trilaurin does not inhibit 5α-reductase activity in prostate tissue samples[1].
Trilaurin (4 mg per plate) shows no mutagenicity in *Salmonella typhimurium* strains TA1535, TA100, TA1537, TA1538, or TA98 with or without metabolic activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Trilaurin (3 times per week; for 20 weeks) completely inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice[1].
Trilaurin (25% w/w; p.o.; mixed into feed; daily; 10 weeks) exerts no toxic effects or induces no body weight changes in weanling rats[1].
Trilaurin (accounting for 36.3% w/w; administered via topical ocular instillation, 3 times) causes mild irritation in rabbits, with a Draize score of 2[1].
Trilaurin (36.3% w/w; administered percutaneously; delivered via occlusive patch) causes no skin irritation in rabbits[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Watanabe (WHHL) rabbits (6 months old); New Zealand white (NZW) rabbits (10 months old)[1]
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Dosage:6.5% w/w
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Administration:oral; mixed in chow diet; 4 days, 1 week
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Result:Increased plasma HDL cholesterol to 250% of baseline and apo A-I to 200% of baseline in 6-month-old WHHL rabbits.
Returned both parameters to baseline after Trilaurin was removed.
Produced similar increases in 10-month-old WHHL and NZW rabbits after 1 week of supplementation.
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Animal Model:Rabbits[1]
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Dosage:36.3% w/w
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Administration:ocular instillation; three times
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Result:Produced a Draize score of 2, classified as mildly irritating to rabbit eyes.
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Animal Model:Rabbits[1]
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Dosage:36.3% w/w
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Administration:topical; occlusive patch application
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Result:Observed no erythema or edema in any rabbits at 2 or 24 hours after patch removal, classifying the test substance as nonirritating to rabbit skin.
Chemical Information
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CAS No. 538-24-9
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Appearance Solid
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분자량 639.00
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화학식 C39H74O6
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Color White to off-white
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SMILES
CCCCCCCCCCCC(OCC(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)=O
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 4 mg/mL (6.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMF : 1 mg/mL (1.56 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Johnson W Jr; Cosmetic Ingredient Review Expert Panel, et al. Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate. Int J Toxicol. 2001;20 Suppl 4:61-94. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / DMSO | 1 mM | 1.5649 mL | 7.8247 mL | 15.6495 mL | 39.1236 mL |
| DMSO | 5 mM | 0.3130 mL | 1.5649 mL | 3.1299 mL | 7.8247 mL |
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