Ulodesine succinate
Based on 1 publication(s) in Google Scholar
Ulodesine succinate (BCX4208 succinate) is a purine nucleoside phosphorylase (PNP) inhibitor, with an IC50 of 2.293 nM against human PNP, and low nanomolar IC50 values against mouse, rat and monkey PNP. Ulodesine succinate blocks the production of uric acid precursors, reduces serum uric acid levels, clears accumulated uric acid in the blood, and elevates the levels of purine nucleosides including guanosine. Ulodesine succinate reduces the counts of total lymphocytes, T lymphocytes and lymphocyte subsets, inhibits the proliferation of cancer cells and activated lymphocytes, and enhances vaccine immune responses. Ulodesine succinate can be used in research related to hyperuricemia and gout.
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- CAS No.: 1246200-39-4
- 화학식: C12H16N4O3·1/2C4H6O4
- 분자량:323.33
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ulodesine succinate
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Biological Activity
제품 설명
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PNP 2.293 nM (IC50) |
In Vitro
Ulodesine succinate exhibits potent nanomolar-range inhibitory activity against PNP, with an IC50 of 2.293 nmol/L[1].
Ulodesine succinate (low nM) potently inhibits PNP and blocks proliferation of T-ALL cell lines at low nM concentrations, inhibits activated normal PBLs with lower potency, and has no effect on HUT102 CTCL cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1246200-39-4
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분자량 323.33
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화학식 C12H16N4O3·1/2C4H6O4
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SMILES
OC(CCC(O)=O)=O.O=C(N=CN1)C2=C1C(CN3C[C@@H]([C@H](C3)O)CO)=CN2.[1/2]
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Synonyms
BCX4208 succinate
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Gut Microbes
Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation. [Abstract]2026 Dec 31;18(1):2620124. PMID: 41605881
Protocol
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
순도&문서
References
[1]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]
[2]. Shahid H, et al. Investigational drugs for hyperuricemia. Expert opinion on investigational drugs. 2015;24(8):1013-30. [Content Brief]
[4]. Tang DH, et al. Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model. Pharm Biol. 2021 Dec;59(1):175-182. [Content Brief]
[5]. Evans GB, et al. Immucillins in Infectious Diseases. ACS infectious diseases. 2018 Feb 09;4(2):107-117. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ulodesine succinate Related Classifications
HY-19480B Related Classifications
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