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Cat. No.: HY-19480B

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Ulodesine succinate

Name: Ulodesine succinate
Brand: MedChemExpress
SKU: HY-19480B
Availability: PreOrder

(Synonyms: BCX4208 succinate)

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

Ulodesine succinate (BCX4208 succinate) is a purine nucleoside phosphorylase (PNP) inhibitor, with an IC₅₀ of 2.293 nM against human PNP, and low nanomolar IC₅₀ values against mouse, rat and monkey PNP. Ulodesine succinate blocks the production of uric acid precursors, reduces serum uric acid levels, clears accumulated uric acid in the blood, and elevates the levels of purine nucleosides including guanosine. Ulodesine succinate reduces the counts of total lymphocytes, T lymphocytes and lymphocyte subsets, inhibits the proliferation of cancer cells and activated lymphocytes, and enhances vaccine immune responses. Ulodesine succinate can be used in research related to hyperuricemia and gout.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1246200-39-4
화학식: C₁₂H₁₆N₄O₃·1/2C₄H₆O₄
분자량:323.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Ulodesine succinate Chemical Structure

CAS No.: 1246200-39-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]^[2]^[3]^[4]^[5]

PNP

2.293 nM (IC₅₀)

In Vitro

OthersAnti-cancerNucleotide Metabolism

Others

Ulodesine succinate exhibits potent nanomolar-range inhibitory activity against PNP, with an IC₅₀ of 2.293 nmol/L^[1].

Anti-cancer

Nucleotide Metabolism

Ulodesine succinate (low nM) potently inhibits PNP and blocks proliferation of T-ALL cell lines at low nM concentrations, inhibits activated normal PBLs with lower potency, and has no effect on HUT102 CTCL cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nucleotide Metabolism

Ulodesine (i.v.) succinate significantly reduces elevated blood uric acid levels and eliminates urate accumulation in hyperuricemic model mice after intravenous administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 1246200-39-4
분자량 323.33
화학식 C₁₂H₁₆N₄O₃·1/2C₄H₆O₄
SMILES

OC(CCC(O)=O)=O.O=C(N=CN1)C2=C1C(CN3C[C@@H]([C@H](C3)O)CO)=CN2.[1/2]
Synonyms

BCX4208 succinate
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Gut Microbes

Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation. [Abstract]

2026 Dec 31;18(1):2620124. PMID: 41605881

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]

[2]. Shahid H, et al. Investigational drugs for hyperuricemia. Expert opinion on investigational drugs. 2015;24(8):1013-30. [Content Brief]

[3]. Bantia S. Purine Nucleoside Phosphorylase Inhibitors as Novel Immuno-Oncology Agent and Vaccine Adjuvant. Int J Immunol Immunother. 2020;7:043.

[4]. Tang DH, et al. Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model. Pharm Biol. 2021 Dec;59(1):175-182. [Content Brief]

[5]. Evans GB, et al. Immucillins in Infectious Diseases. ACS infectious diseases. 2018 Feb 09;4(2):107-117. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Ulodesine succinate

1 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References

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Ulodesine succinate

Publications Citing Use of MedChemExpress (MCE) Ulodesine succinate