VU0400195
VU0400195 (ML182) is a oral active and allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4) with the EC50 of 291 nM. VU0400195 can be used for study of antiparkinsonian animal model.
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- CAS No.: 1309434-83-0
- 화학식: C21H16ClN3O3
- 분자량:393.82
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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hmGluR4a 291 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
291 nM
Compound: 15f, VU0400195, ML182, diastereomeric mixture
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Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay
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[PMID: 21966889] |
| HEK293 | EC50 |
1.7 μM
Compound: 15f, VU0400195, ML182, diastereomeric mixture
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Positive allosteric modulator activity at rat mGlu5 receptor expressed in human HEK293 at 10 uM by calcium mobilization assay
Positive allosteric modulator activity at rat mGlu5 receptor expressed in human HEK293 at 10 uM by calcium mobilization assay
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[PMID: 21966889] |
Chemical Information
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CAS No. 1309434-83-0
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분자량 393.82
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화학식 C21H16ClN3O3
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SMILES
O=C(C1=NC=CC=C1)NC2=CC=C(C(Cl)=C2)N3C([C@@]4([C@@]5([H])C[C@@]([H])([C@]4([H])C3=O)C=C5)[H])=O
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Synonyms
ML182
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Jones CK, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. J Med Chem. 2011 Nov 10;54(21):7639-47. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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