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Cat. No.: HY-12371

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VU0431316

VU0431316 is a potent and selective non-competitive antagonist of mGlu5 with an IC₅₀ value of 24 nM.

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CAS No.: 1620203-63-5
화학식: C₁₄H₉ClN₆O₂
분자량:328.71

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

VU0431316 Chemical Structure

CAS No.: 1620203-63-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

VU0431316 is a potent and selective non-competitive antagonist of mGlu5 with an IC₅₀ value of 24 nM^[1].

All mGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293-A	IC₅₀	62.4 nM Compound: 68, VU0431316	Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilization Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilization	[PMID: 24969015]

Chemical Information

CAS No. 1620203-63-5
분자량 328.71
화학식 C₁₄H₉ClN₆O₂
SMILES

O=C(C1=NC=CC(Cl)=C1)NC2=NC(OC3=CN=CN=C3)=CN=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Brittney S Bates, et al. Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3307-14. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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VU0431316

All mGluR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

VU0431316 Related Classifications

HY-12371 Related Classifications