country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183855

Copy Link Print Information

WF-2421

WF-2421 is an aldose reductase inhibitor with an IC₅₀ of 0.03 μM against rabbit-derived aldose reductase. WF-2421 acts as a non-competitive inhibitor of aldose reductase using dl-glyceraldehyde as the substrate. WF-2421 can be used in the research of diabetic complications (cataract, neuropathy, retinopathy, nephropathy).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 128429-19-6
화학식: C₁₉H₂₀N₂O₈
분자량:404.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

WF-2421 Chemical Structure

CAS No.: 128429-19-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

WF-2421 (2 minutes) potently inhibits partially purified rabbit lens aldose reductase with an IC₅₀ of 0.03 μM, acting as an uncompetitive inhibitor relative to DL-glyceraldehyde (HY-128748)^[1].
WF-2421 sodium salt exhibits no antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Trichophyton asteroides, or Candida albicans at 1 mg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 128429-19-6
분자량 404.37
화학식 C₁₉H₂₀N₂O₈
SMILES

O=CNCC(C1=CC(C2=CC(C(C(C(O)=O)NC=O)O)=CC=C2O)=C(O)C=C1)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Nishikawa M, et al. WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea. J Antibiot (Tokyo). 1991;44(2):130-135. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기