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Cat. No.: HY-N19876

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WF-5239

WF-5239 is a fungal metabolite can be found in Aspergillus fumigatus Fresenius. WF-5239 potently inhibits platelet aggregation. WF-5239 can be used for the research of pulmonary thrombosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 91224-36-1
화학식: C₉H₉NO₂
분자량:163.17

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

WF-5239 Chemical Structure

CAS No.: 91224-36-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

WF-5239 is a fungal metabolite can be found in Aspergillus fumigatus Fresenius. WF-5239 potently inhibits platelet aggregation. WF-5239 can be used for the research of pulmonary thrombosis^[1].

IC₅₀ & Target

^[1]

Fungal Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

WF-5239 (2 minutes) potently inhibits Arachidonic acid (HY-109590)- and Collagen (HY-NP003)-induced aggregation in rabbit platelet-rich plasma, with IC₅₀ values of 1.25 μg/mL and 5.0 μg/mL respectively, and has no meaningful activity against ADP- or Thrombin (HY-114164)-induced aggregation^[1].
WF-5239 (100 μg/mL) exhibits no antimicrobial activity against yeasts, fungi, bacteria, or mycobacteria at 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WF-5239 (3-30 mg/kg; i.p.; single dose) improves survival in a mouse model of Arachidonic acid-induced pulmonary thrombosis, with 80% survival observed at 30 mg/kg ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ddY (male, 15~20 g, pulmonary thrombosis induced by sodium Arachidonic acid slow tail vein injection)^[1]
Dosage:

3 mg/kg; 10 mg/kg; 30 mg/kg
Administration:

i.p.; single dose
Result:

Increased survival rate to 80% in 10 treated mice at 30 mg/kg.
Increased survival rate to 40% in 10 treated mice at 10 mg/kg.
Increased survival rate to 10% in 10 treated mice at 3 mg/kg.

Chemical Information

CAS No. 91224-36-1
분자량 163.17
화학식 C₉H₉NO₂
SMILES

O=CN/C=C\C1=CC=C(C=C1)O
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
Aspergillus fumigatus
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Umehara K, et al. Studies on WF-5239, a new potent platelet aggregation inhibitor. J Antibiot (Tokyo). 1984;37(5):469-474. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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