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Cat. No.: HY-156730R

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KT-333 (Standard)

KT-333 (Standard) is the analytical standard of KT-333 (HY-156730). This product is intended for research and analytical applications. KT-333 is a molecular glues that degrades STAT3 protein. KT-333 mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL). KT-333 has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL).

For research use only. We do not sell to patients.

CAS No.: 2502186-79-8
Formula: C₆₀H₇₄ClN₁₀O₁₄PS
Molecular Weight:1257.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KT-333 (Standard) Chemical Structure

CAS No.: 2502186-79-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2502186-79-8
Molecular Weight 1257.78
Formula C₆₀H₇₄ClN₁₀O₁₄PS
SMILES

O=C([C@H]1N(C([C@H](C2)NC(C3=CC4=CC(C([P](O)(O)=O)=O)=CC=C4N3)=O)=O)[C@](CCN2C(C)=O)([H])CC1)N[C@@H](CCC(N)=O)COC(C=CC=C5CCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]6O)[C@@H](C6)C(N[C@H](C7=CC=C(C(SC=N8)=C8C)C=C7)C)=O)=O)=O)=C5Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Phillip CC Liu, et al. A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers. Blood. Volume 138, Supplement 1, 23 November 2021, Page 1865

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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