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Lats-IN-1 

Cat. No.: HY-138489
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Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues.

For research use only. We do not sell to patients.

Lats-IN-1 Chemical Structure

Lats-IN-1 Chemical Structure

CAS No. : 1424635-83-5

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Description

Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].

In Vitro

The IC50 for Lats-IN-1 increases with the ATP concentration[1].
Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC50 of 510 nM[1].
Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids[1].
Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF 10A cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Decreased the phosphorylation of Yap at residue S127.
Molecular Weight

334.39

Formula

C₁₈H₁₄N₄OS

CAS No.

1424635-83-5

SMILES

O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Lats-IN-1OthersInhibitorinhibitorinhibit

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Lats-IN-1
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