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LP-184 

Cat. No.: HY-139453
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LP-184 (compound 6), an acylfulvene analog, inhibits tumor growth. LP-184 has potent anti-cancer activity in the ovarian, colon, prostate and pancreatic cell lines. (patent WO2007019308A2).

For research use only. We do not sell to patients.

LP-184 Chemical Structure

LP-184 Chemical Structure

CAS No. : 924835-67-6

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Description

LP-184 (compound 6), an acylfulvene analog, inhibits tumor growth. LP-184 has potent anti-cancer activity in the ovarian, colon, prostate and pancreatic cell lines. (patent WO2007019308A2).

IC50 & Target

IC50: 0.68 μM (HT29); 0.6 μM (OVCAR-3); 16 μM (AsPC-1); 0.14 μM (PC-3)

In Vitro

LP-184 inhibits the growth of HT29, OVCAR-3, AsPC-1 and PC-3, with GI50s of 0.68, 0.6, 16 and 0.14 μM, respectively[1].
LP-184 displays IC50s of 800nM and 210 nM for anti-cancer activitie in the thymidine incorporation into cellular DNA (2 hour) and Trypan blue (48 hour) assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LP-184 (7.5 and 10 mg/kg; i.p.; 21 day) has potent 15 anti-tumor activity against MV522 tumors, producing 4/6 and 5/5 partial responses, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (MV522 tumors) [1]
Dosage: 7.5 and 10 mg/kg
Administration: I.p; 21day
Result: Effective agent for human anti-tumor therapy.
Molecular Weight

304.34

Formula

C₁₆H₂₀N₂O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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LP-184
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