1. Epigenetics
  2. Histone Demethylase
  3. LSD1/2-IN-4

LSD1/2-IN-4 

Cat. No.: HY-151194
Handling Instructions

LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL).

For research use only. We do not sell to patients.

LSD1/2-IN-4 Chemical Structure

LSD1/2-IN-4 Chemical Structure

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Description

LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL)[1].

IC50 & Target

Ki: 0.11 μM (LSD1); 130 μM (LSD2)[1]

In Vitro

LSD1/2-IN-4 shows strong inhibitory activity against both LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively and not inhibits peroxidase with an IC50 >500 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

248.07

Formula

C9H8BrF2N

SMILES

N[[email protected]@H]1C[[email protected]]1C2=CC(F)=C(Br)C(F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
LSD1/2-IN-4
Cat. No.:
HY-151194
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