2. Epigenetics
  3. Histone Demethylase
  4. LSD1/2-IN-4

LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL).

For research use only. We do not sell to patients.

LSD1/2-IN-4 Chemical Structure

LSD1/2-IN-4 Chemical Structure

CAS No. : 2821068-09-9

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LSD1/2-IN-4 Related Antibodies

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Description

LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL)[1].

IC50 & Target

KDM1/LSD1

 

In Vitro

LSD1/2-IN-4 shows strong inhibitory activity against both LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively and not inhibits peroxidase with an IC50 >500 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LSD1/2-IN-4 Related Antibodies
Molecular Weight

248.07

Formula

C9H8BrF2N
CAS No.
SMILES

N[C@@H]1C[C@H]1C2=CC(F)=C(Br)C(F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LSD1/2-IN-4 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1/2-IN-42821068-09-9Histone DemethylasePCPA derivativelysine-specific demethylase 1 (LSD1)lysine-specific demethylase 2 (LSD2)T-cell acute lymphoblastic leukemia (TALL)cancerInhibitorinhibitorinhibit

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