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Cat. No.: HY-149595

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LSD1-UM-109

LSD1-UM-109 is a ighly potent and reversible LSD1 inhibitor with an IC₅₀ of 3.1 nM. LSD1-UM-109 inhibits cell growth with IC₅₀ values of 0.6 nM in the MV4;11 acute leukemia cell line and 1.1 nM in the H1417 small-cell lung cancer cell line.

For research use only. We do not sell to patients.

CAS No.: 2252446-26-5
Formula: C₂₉H₂₇FN₆
Molecular Weight:478.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

LSD1-UM-109 Chemical Structure

CAS No.: 2252446-26-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

LSD1

3.1 nM (IC₅₀)

All Histone Demethylase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	IC₅₀	31 nM Compound: 46; LSD1-UM-109	Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition incubated for 7 days by WST-8 assay Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition incubated for 7 days by WST-8 assay	[PMID: 37849536]
MV4-11	IC₅₀	0.6 nM Compound: 46; LSD1-UM-109	Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 10 days by WST-8 assay Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 10 days by WST-8 assay	[PMID: 37849536]
NCI-H1417	IC₅₀	1.1 nM Compound: 46; LSD1-UM-109	Antiproliferative activity against human NCI-H1417 cells assessed as cell growth inhibition incubated for 10 days by WST-8 assay Antiproliferative activity against human NCI-H1417 cells assessed as cell growth inhibition incubated for 10 days by WST-8 assay	[PMID: 37849536]

Chemical Information

CAS No. 2252446-26-5
Molecular Weight 478.56
Formula C₂₉H₂₇FN₆
SMILES

CN(N=C1)C2=C1C=C(C=C2)C3=C(C4=CC=C(C#N)C(F)=C4)C5=C(N(CC6(C)CCNCC6)C=C5)C=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Canhui Zheng, et al. Discovery of Pyrrolo[2,3- c]pyridines as Potent and Reversible LSD1 Inhibitors. ACS Med Chem Lett. 2023 Sep 21;14(10):1389-1395. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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