m-CPBG hydrochloride
Based on 1 Customer Validation
m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.85%
- CAS. Nr.: 2113-05-5
- Formel: C8H11Cl2N5
- Molecular Weight:248.12
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Speicherung:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
5-HT3 Receptor |
In Vivo
m-CPBG hydrochloride (third ventricle injection; 160 nM) significantly inhibits water intake in hypovolemic animals[1].
m-CPBG hydrochloride (third ventricle injection; 320 nM) decreases water intake in water-deprived rats[1].
m-CPBG hydrochloride (central administration） inhibits water intake induced by pharmacological activation of central cholinergic and angiotensinergic pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar male rats[1]
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Dosage:80, 160 and 320 nM
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Administration:Ventricle injection
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Result:Decreased water intake induced by water deprivation, acute salt load and hypovolemia.
Chemical Information
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CAS. Nr. 2113-05-5
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Appearance Solid
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Molecular Weight 248.12
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Formel C8H11Cl2N5
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Color White to off-white
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SMILES
NC(NC(NC1=CC=CC(Cl)=C1)=N)=N.Cl
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Synonyms
1-(3-Chlorophenyl)biguanide hydrochloride
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 100 mg/mL (403.03 mM; Need ultrasonic)
DMSO : 5.83 mg/mL (23.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Research Protocol for Neurological Diseases
PINK1/Parkin-mediated mitophagy pathway is a mitochondrial quality-control signaling axis in which mitochondrial depolarization stabilizes PINK1 on damaged mitochondria, activates Parkin recruitment and E3 ubiquitin ligase activity, promotes ubiquitination of outer mitochondrial membrane proteins, recruits selective autophagy adaptors, and drives lysosomal degradation of damaged mitochondria. In neurological disease research, this pathway is experimentally important because neurons, especially dopaminergic neurons, are highly dependent on mitochondrial integrity, and defective mitochondrial turnover can lead to mitochondrial dysfunction, oxidative stress, impaired neuronal survival, α-synuclein accumulation, and neuroinflammatory damage-associated signals. The genetic disease link is strongest in Parkinson’s disease because mutations in PRKN/parkin cause autosomal recessive juvenile parkinsonism, mutations in PINK1 cause hereditary early-onset Parkinson’s disease, and Drosophila studie
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.0303 mL | 20.1515 mL | 40.3031 mL | 100.7577 mL |
| 5 mM | 0.8061 mL | 4.0303 mL | 8.0606 mL | 20.1515 mL | |
| 10 mM | 0.4030 mL | 2.0152 mL | 4.0303 mL | 10.0758 mL | |
| 15 mM | 0.2687 mL | 1.3434 mL | 2.6869 mL | 6.7172 mL | |
| 20 mM | 0.2015 mL | 1.0076 mL | 2.0152 mL | 5.0379 mL | |
| H2O | 25 mM | 0.1612 mL | 0.8061 mL | 1.6121 mL | 4.0303 mL |
| 30 mM | 0.1343 mL | 0.6717 mL | 1.3434 mL | 3.3586 mL | |
| 40 mM | 0.1008 mL | 0.5038 mL | 1.0076 mL | 2.5189 mL | |
| 50 mM | 0.0806 mL | 0.4030 mL | 0.8061 mL | 2.0152 mL | |
| 60 mM | 0.0672 mL | 0.3359 mL | 0.6717 mL | 1.6793 mL | |
| 80 mM | 0.0504 mL | 0.2519 mL | 0.5038 mL | 1.2595 mL | |
| 100 mM | 0.0403 mL | 0.2015 mL | 0.4030 mL | 1.0076 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
m-CPBG hydrochloride Related Classifications
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