M1 receptor modulator-1
M1 receptor modulator-1 is a low-efficacy positive allosteric modulator of the muscarinic M1 receptor (mAChR1), with an EC50 of 71 nM for the human M1 receptor. M1 receptor modulator-1 enables use-dependent attenuation of neurotransmitter signals and exhibits excellent in vivo properties without pseudo-agonist activity. M1 receptor modulator-1 can be used in research related to Alzheimer's disease and schizophrenia.
For research use only. We do not sell to patients.
- CAS No.: 34099-70-2
- Formula: C15H11BrN2S
- Molecular Weight:331.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mAChR1 71 nM (EC50) |
M1 receptor modulator-1 (Compound 52)(up to 10,000 nM; up to 24 μM; 10 μM) is a potent, selective low-shift positive allosteric modulator of human and rat muscarinic M1 receptors, with an EC50 of 71 nM at human M1 receptors, and exhibits favorable drug metabolism properties in human and mouse microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 34099-70-2
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Molecular Weight 331.23
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Formula C15H11BrN2S
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SMILES
S=C1NC2=C(C(C3=CC=CC=C3)=NC1)C=C(Br)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
M1 receptor modulator-1 Related Classifications
HY-184057 Related Classifications
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