M1002
Based on 2 publication(s) in Google Scholar
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors.
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- Pureté: 99.69%
- CAS No.: 823830-85-9
- Formule: C15H8F6N2O2S
- Masse moléculaire:394.30
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) M1002
More
Activité biologique
M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy[1].
M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:786-O cells
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Concentration:10 μM
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Incubation Time:24 hours
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Result:Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control.
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Cell Line:Hep3B cells
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Concentration:5 μM
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Incubation Time:24 hours
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Result:Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment.
Chemical Information
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CAS No. 823830-85-9
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Appearance Solid
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Masse moléculaire 394.30
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Formule C15H8F6N2O2S
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Color White to off-white
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SMILES
O=S1(N=C(C2=C1C=CC=C2)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia. [Abstract]2025 Oct 1. PMID: 41034402 -
Biochem Pharmacol
The 'ABC' of split-nanoluciferase HIF heterodimerization bioassays: Applications, Benefits & Considerations. [Abstract]2024 Aug 9:116478. PMID: 39128589
Solvant et solubilité
DMF : 50 mg/mL (126.81 mM; Need ultrasonic)
DMSO : 50 mg/mL (126.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / DMSO | 1 mM | 2.5362 mL | 12.6808 mL | 25.3617 mL | 63.4041 mL |
| 5 mM | 0.5072 mL | 2.5362 mL | 5.0723 mL | 12.6808 mL | |
| 10 mM | 0.2536 mL | 1.2681 mL | 2.5362 mL | 6.3404 mL | |
| 15 mM | 0.1691 mL | 0.8454 mL | 1.6908 mL | 4.2269 mL | |
| 20 mM | 0.1268 mL | 0.6340 mL | 1.2681 mL | 3.1702 mL | |
| 25 mM | 0.1014 mL | 0.5072 mL | 1.0145 mL | 2.5362 mL | |
| 30 mM | 0.0845 mL | 0.4227 mL | 0.8454 mL | 2.1135 mL | |
| 40 mM | 0.0634 mL | 0.3170 mL | 0.6340 mL | 1.5851 mL | |
| 50 mM | 0.0507 mL | 0.2536 mL | 0.5072 mL | 1.2681 mL | |
| 60 mM | 0.0423 mL | 0.2113 mL | 0.4227 mL | 1.0567 mL | |
| 80 mM | 0.0317 mL | 0.1585 mL | 0.3170 mL | 0.7926 mL | |
| 100 mM | 0.0254 mL | 0.1268 mL | 0.2536 mL | 0.6340 mL |
M1002 Related Classifications
HY-139287 Related Classifications
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