Manool 

Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle^[1][2].

Manool exhibits higher cytotoxic activity against HeLa (IC₅₀=6.7 µg/mL) and U343 (IC₅₀=6.7 µg/mL) cells^[1].
Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

290.48

Solid

C₂₀H₃₄O

596-85-0

CC(CCC1)(C)[[email protected]]([[email protected]@]1(C)[[email protected]]2CC[[email protected]](O)(C)C=C)([H])CCC2=C

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. de Oliveira PF, et al. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-2143.  [Content Brief]

  [2]. Pratsinis H, et al. Antiproliferative activity of Greek propolis. J Med Food. 2010;13(2):286-290.  [Content Brief]

  [3]. Nicolella HD, et al. Differential effect of manool--a diterpene from Salvia officinalis, on genotoxicity induced by methyl methanesulfonate in V79 and HepG2 cells. Food Chem Toxicol. 2014;72:8-12.  [Content Brief]