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Cat. No.: HY-W712676

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Methacryloyl-CoA

Name: Methacryloyl-CoA
Brand: MedChemExpress
SKU: HY-W712676
Availability: PreOrder

(Synonyms: Methacrylyl-coenzyme A)

Methacryloyl-CoA (Methacrylyl-coenzyme A) is a thiol-reactive toxic intermediate produced by mitochondrial valine catabolism that inhibits thiol-containing mitochondrial enzymes through reaction with thiols. Methacryloyl-CoA is metabolically detoxified by MC-CoA hydratase and HIB-CoA hydrolase, and reduced activity of its metabolic enzymes weakens detoxification capacity. Methacryloyl-CoA can be used in research on cirrhosis and hepatocellular carcinoma.

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CAS No.: 6008-91-9
Formule: C₂₅H₄₀N₇O₁₇P₃S
Masse moléculaire:835.61

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Methacryloyl-CoA Chemical Structure

CAS No.: 6008-91-9

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Methacryloyl-CoA (Methacrylyl-coenzyme A) (MAA-CoA) (2 days) cannot support detectable WT GumG-mediated acyl transfer to PenΔFGL in the one-pot assay^[1].
Methacryloyl-CoA (2 days) cannot support detectable GumG-mediated acylation of D-Man by WT GumG or the tested GumG variants^[1].
Methacryloyl-CoA (3 days) does not produce detectable methacrylated xanthan gum in Xcc ΔgumL (pStlig) cultures^[1].
Methacryloyl-CoA shows no significant hydratase activity with recombinant MBP-tagged E. coli PaaZ in spectrophotometric enoyl-CoA assays^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Liver Cancer Modeling

Chemical Information

CAS No. 6008-91-9
Masse moléculaire 835.61
Formule C₂₅H₄₀N₇O₁₇P₃S
SMILES

O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C(C)=C)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
Synonyms

Methacrylyl-coenzyme A
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liu Y, et al. Unraveling Xanthomonas acetyltransferase GumG: decoding catalytic promiscuity, understanding the mechanism, and enhancing enzymatic versatility[J]. bioRxiv, 2026: 2026.06. 22.733816.

[2]. Teufel R, et al. Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point. J Biol Chem. 2011 Apr 1;286(13):11021-34.

[3]. Ishigure K, et al. Human liver disease decreases methacrylyl-CoA hydratase and beta-hydroxyisobutyryl-CoA hydrolase activities in valine catabolism. Clinica chimica acta; international journal of clinical chemistry. 2001 Oct;312(1-2):115-21.

[4]. Wei S, et al. Differentiating hepatocellular carcinoma from hepatitis C using metabolite profiling. Metabolites. 2012 Oct 10;2(4):701-16.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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