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Methylcobalamin hydrate

(Synonyms: Mecobalamin hydrate)
6 Cited Publications
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Based on 6 publication(s) in Google Scholar

Methylcobalamin Hydrate is a coenzyme required for methionine biosynthesis. Vitamins (hematopoiesis). It acts as a histamine receptor, Alzheimer study. Methylcobalamin is also used in the research of peripheral neuropathy, diabetic neuropathy, and as an initial research for amyotrophic lateral sclerosis. It can be used to prevent or research pathologies caused by vitamin B12 deficiency, such as pernicious anemia.

For research use only. We do not sell to patients.

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  • Methylcobalamin hydrate Chemical Structure
    Methylcobalamin hydrate Chemical Structure
  • Experimental Validation Results for Methylcobalamin hydrate
  • Experimental Validation Results for Methylcobalamin hydrate
  • Experimental Validation Results for Methylcobalamin hydrate
  • Experimental Validation Results for Methylcobalamin hydrate
  • Experimental Validation Results for Methylcobalamin hydrate
CAS No.: 288315-09-3
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Bio/Physico-chemical AssayWBCell Imaging/StainingIn Vivo Efficacy Study
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  • In Vivo Efficacy Study
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  • Methylcobalamin hydrate Chemical Structure
    Methylcobalamin hydrate Chemical Structure
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    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

    Customer Validation
     MST measurements of the binding of 0.2 μM recombinant caspase-3, GSDME, GSDMD with Methylcobalamin (MeCbl) or positive control. Methylcobalamin (MeCbl) specifically bound to GSDME but not to caspase-3 or GSDMD.

  • 1/16

    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

    Customer Validation
     Representative immunoblot of GSDME pretreated with inhibitors as indicated, and then incubated with recombinant active caspase-3 for GSDME activation analysis. GSDME cleavage by caspase-3 was potently disrupted by Methylcobalamin (MeCbl) (1 μM; 30 min).

  • 1/16

    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

    Customer Validation
     Changes in HepG2 cell morphology were observed with a microscope. Methylcobalamin (MeCbl) (20 μM; 2h) obviously blocked the appearance of pyroptotic bubbles (red arrow).

  • 1/16

    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

    Customer Validation
     SYTOX fluorescence probe was used to investigate the protective effects of Methylcobalamin (MeCbl) (20 μM) on DCA-induced systemic and liver injury. The liver region was indicated with a red or yellow circle. Methylcobalamin (MeCbl) was effective against DCA-induced liver damage of zebrafish.

  • 1/16

    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

    Customer Validation
     Methylcobalamin (MeCbl) (10 mg/kg; i.g.; once daily) treatment drastically reduced Serum transaminase ALT/AST activities, IL-1α and IL-1β in wild-type six-week-old C57BL/6J male mice.

  • Methylcobalamin hydrate