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Methylcobalamin hydrate  (Synonyms: Mecobalamin hydrate)

Cat. No.: HY-W127737
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Methylcobalamin Hydrate is a coenzyme required for methionine biosynthesis. Vitamins (hematopoiesis). It acts as a histamine receptor, Alzheimer study. Methylcobalamin is also used in the research of peripheral neuropathy, diabetic neuropathy, and as an initial research for amyotrophic lateral sclerosis. It can be used to prevent or research pathologies caused by vitamin B12 deficiency, such as pernicious anemia.

For research use only. We do not sell to patients.

CAS No. : 288315-09-3

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Methylcobalamin hydrate:

Methylcobalamin hydrate Related Antibodies

Top Publications Citing Use of Products

    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233.  [Abstract]

    MST measurements of the binding of 0.2 μM recombinant caspase-3, GSDME, GSDMD with Methylcobalamin (MeCbl) or positive control. Methylcobalamin (MeCbl) specifically bound to GSDME but not to caspase-3 or GSDMD.

    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233.  [Abstract]

    Representative immunoblot of GSDME pretreated with inhibitors as indicated, and then incubated with recombinant active caspase-3 for GSDME activation analysis. GSDME cleavage by caspase-3 was potently disrupted by Methylcobalamin (MeCbl) (1 μM; 30 min).

    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233.  [Abstract]

    Changes in HepG2 cell morphology were observed with a microscope. Methylcobalamin (MeCbl) (20 μM; 2h) obviously blocked the appearance of pyroptotic bubbles (red arrow).

    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233.  [Abstract]

    SYTOX fluorescence probe was used to investigate the protective effects of Methylcobalamin (MeCbl) (20 μM) on DCA-induced systemic and liver injury. The liver region was indicated with a red or yellow circle. Methylcobalamin (MeCbl) was effective against DCA-induced liver damage of zebrafish.

    Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233.  [Abstract]

    Methylcobalamin (MeCbl) (10 mg/kg; i.g.; once daily) treatment drastically reduced Serum transaminase ALT/AST activities, IL-1α and IL-1β in wild-type six-week-old C57BL/6J male mice.

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    Description

    Methylcobalamin Hydrate is a coenzyme required for methionine biosynthesis. Vitamins (hematopoiesis). It acts as a histamine receptor, Alzheimer study. Methylcobalamin is also used in the research of peripheral neuropathy, diabetic neuropathy, and as an initial research for amyotrophic lateral sclerosis. It can be used to prevent or research pathologies caused by vitamin B12 deficiency, such as pernicious anemia.

    Formula

    C63H91CoN13O14P.xH2O
    CAS No.
    SMILES

    [CH3-][Co+3]([N-]1[C@]([C@@H]2CC(N)=O)([H])[C@]3([C@](C)4CC(N)=O)C)([N](C([C@](C)5CC(N)=O)=C6C)=C7[C@H]5CCC(N)=O)([N](C(C(C)8C)=C7)=C([C@H]8CCC(N)=O)C(C)=C1[C@@]2(CCC(NC[C@H]9C)=O)C)([N](C%10=C%11)=CN([C@@H](O[C@@H]%12CO)[C@]([C@@H]%12O[P]([O-])(O9)=O)([H])O)C%10=CC(C)=C%11C)[N]3=C6[C@H]4CCC(N)=O.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    Methylcobalamin hydrate Related Classifications

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    The molarity calculator equation

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    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Methylcobalamin288315-09-3MecobalaminBiochemical Assay Reagentsbiochemical assayreagentInhibitorinhibitorinhibit

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