ML-7 hydrobromide (Standard)
ML-7 hydrochloride (Standard) is the analytical standard of ML-7 hydrochloride (HY-15417). This product is intended for research and analytical applications. ML-7 hydrochloride is a selective and highly specific myosin light chain Kinase (MLCK) inhibitor that acts as a trabecular meshwork (TM) relaxant. ML-7 hydrochloride enhances Quinocetone (HY-123581)-induced phosphorylation of ERK, p38 MAPK and JNK, attenuates Akt activation, and promotes apoptosis of hepatocellular carcinoma cells. ML-7 hydrochloride reduces Th2 cytoKine secretion by inhibiting MLCK, while alleviating smooth muscle hyperplasia and collagen deposition. As a non-antibiotic adjuvant, ML-7 hydrochloride restores the sensitivity of drug-resistant bacteria to Tigecycline (HY-B0117). ML-7 hydrochloride can be used in research related to glaucoma, hepatocellular carcinoma, asthma, and Klebsiella pneumoniae infection.
For research use only. We do not sell to patients.
- CAS No.: 110448-33-4
- Formula: C15H18ClIN2O2S
- Molecular Weight:452.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 110448-33-4
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Molecular Weight 452.74
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Formula C15H18ClIN2O2S
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SMILES
O=S(N1CCNCCC1)(C2=C3C=CC=C(I)C3=CC=C2)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- ML-7 hydrobromide (Standard)
- 110448-33-4
- Reference Standards
- Myosin
- ERK
- JNK
- p38 MAPK
- Akt
- Apoptosis
- Bacterial
- Extracellular signal regulated kinases
- c-Jun N-terminal kinase
- PKB
- Protein kinase B
- tigecycline-resistant Klebsiella pneumoniae
- myosin light chain kinase
- Bax/Bcl-2 ratio
- HepG2 cells
- human neutrophils
- caspase-8
- Inhibitor
- inhibitor
- inhibit