1. JAK/STAT Signaling Stem Cell/Wnt
  2. STAT
  3. MM-206

MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines.

For research use only. We do not sell to patients.

MM-206 Chemical Structure

MM-206 Chemical Structure

CAS No. : 1809581-87-0

Size Price Stock Quantity
5 mg USD 231 In-stock
10 mg USD 370 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines[1].

Molecular Weight

497.46

Formula

C22H12F5NO3S2

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=C(C(F)=C(C(F)=C1F)F)F)(NC2=C3C=CC=CC3=C(C(SC4=CC=CC=C4)=C2)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 25 mg/mL (50.26 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0102 mL 10.0511 mL 20.1021 mL
5 mM 0.4020 mL 2.0102 mL 4.0204 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.0102 mL 10.0511 mL 20.1021 mL 50.2553 mL
5 mM 0.4020 mL 2.0102 mL 4.0204 mL 10.0511 mL
10 mM 0.2010 mL 1.0051 mL 2.0102 mL 5.0255 mL
15 mM 0.1340 mL 0.6701 mL 1.3401 mL 3.3504 mL
20 mM 0.1005 mL 0.5026 mL 1.0051 mL 2.5128 mL
25 mM 0.0804 mL 0.4020 mL 0.8041 mL 2.0102 mL
30 mM 0.0670 mL 0.3350 mL 0.6701 mL 1.6752 mL
40 mM 0.0503 mL 0.2513 mL 0.5026 mL 1.2564 mL
50 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0051 mL
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MM-206 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MM-206
Cat. No.:
HY-121725
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