Cat. No.: HY-B0189B

Mosapride citrate dihydrate

(Synonyms: TAK-370 citrate dihydrate; AS-4370 citrate dihydrate)

6 Cited Publications

Customer Review

Based on 6 publication(s) in Google Scholar

Mosapride (TAK-370) citrate dehydrate is a gastroprokinetic agent with 5-hydroxytryptamine₄ receptor agonist activity and has been widely used in the research of a variety of gastrointestinal disorders. Mosapride citrate dihydrate potently inhibits Kv4.3 in a concentration-dependent manner with IC₅₀ values of 15.2 μM. Mosapride citrate dihydrateselectively stimulates upper GI motility in vivo.

For research use only. We do not sell to patients.

Purity: 99.59%
CAS No.: 636582-62-2
Formula: C₂₇H₃₇ClFN₃O₁₂
Molecular Weight:650.05

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Mosapride citrate dihydrate Chemical Structure

CAS No.: 636582-62-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (6)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Mosapride (TAK-370) citrate dehydrate is a gastroprokinetic agent with 5-hydroxytryptamine₄ receptor agonist activity and has been widely used in the research of a variety of gastrointestinal disorders. Mosapride citrate dihydrate potently inhibits Kv4.3 in a concentration-dependent manner with IC₅₀ values of 15.2 μM^[1]. Mosapride citrate dihydrateselectively stimulates upper GI motility in vivo^[2].

IC₅₀ & Target

5-HT₄ Receptor

Kv4.3

15.2 μM (IC₅₀)

All 5-HT Receptor Isoforms :

All Cytochrome P450 Isoforms :

In Vitro

Mosapride (0.3-30 μM) exhibits an inhibitory activity against Kv4.3 with an IC₅₀ of 15.2 μM in a concentration-dependent manner. Mosapride also inhibits the open state of Kv4.3 currents during depolarization and accelerates the closed-state inactivation at subthreshold potentials^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Beagle dogs^[2]
Dosage:

0.3-3 mg/kg
Administration:

Intravenous injection; 0.3-3 mg/kg
Result:

Increased the antral motor activity dose-dependently in conscious dogs.

Chemical Information

CAS No. 636582-62-2
Appearance Solid
Molecular Weight 650.05
Formula C₂₇H₃₇ClFN₃O₁₂
Color White to off-white
SMILES

O=C(NCC1CN(CC2=CC=C(F)C=C2)CCO1)C3=CC(Cl)=C(N)C=C3OCC.O=C(CC(C(O)=O)(O)CC(O)=O)O.O.O
Synonyms

TAK-370 citrate dihydrate; AS-4370 citrate dihydrate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (6)

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Journal Impact Factor

J Ethnopharmacol

Yiqi Kaimi prescription regulates protein phosphorylation to promote intestinal motility in slow transit constipation. [Abstract]

2024 Jul 15:329:118118. PMID: 38614261
Chin J Integr Med

Zhizhu Decoction Alleviates Intestinal Barrier Damage via Regulating SIRT1/FoxO1 Signaling Pathway in Slow Transit Constipation Model Mice. [Abstract]

2023 Sep;29(9):809-817. PMID: 36044116
Dig Dis Sci

Kaempferol Ameliorates Functional Constipation in Mice by Regulating Autophagy of Interstitial Cells of Cajal via the p53/AMPK/mTOR Axis. [Abstract]

2025 Nov 15. PMID: 41240265
J Appl Microbiol

Houpo Paiqi Mixture Promotes Intestinal Motility in Constipated Rats by Modulating Gut Microbiota and Activating 5-HT-cAMP-PKA Signal Pathway. [Abstract]

2023 Aug 1;134(8):lxad153. PMID: 37481692
Drug Metab Pharmacokinet

Influence of gastrointestinal activity on the absorption of nilotinib. [Abstract]

2020 Feb;35(1):102-110. PMID: 31732429
Nat Prod Commun

2025 Jul 21.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sung KW, et al. Effect of mosapride on Kv4.3 potassium channels expressed in CHO cells. Naunyn-Schmiedeberg's archives of pharmacology. 2013;386(10):905-16. [Content Brief]

[2]. Mine Y, et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. The Journal of pharmacology and experimental therapeutics. 1997;283(3):1000-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Mosapride citrate dihydrate

6 Cited Publications

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Mosapride citrate dihydrate

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Publications Citing Use of MedChemExpress (MCE) Mosapride citrate dihydrate

All 5-HT Receptor Isoforms

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Publications (6)

Purity & Documentation

References

Calculators

Help & FAQs

Mosapride citrate dihydrate Related Classifications

HY-B0189B Related Classifications