Cat. No.: HY-L009

Kinase Inhibitor Library

123 Cited Publications

Customer Review

Based on 123 publication(s) in Google Scholar

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3,949 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Service

Kinase Screening Service

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (123)
Documentation
Composition

Description & Advantages

• A unique collection of 3,949 phosphorylation kinase inhibitors/regulators for high throughput screening (HTS) and high content screening (HCS).

• The library contains compounds targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase).

• Kinase inhibitors have played an increasingly prominent role in the treatment of cancer and other diseases.

• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

• Structurally diverse, medicinally active, and cell permeable.

• Rich documentation with structure, IC₅₀, and customer reviews.

• NMR and HPLC validated to ensure high purity.

• All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 3,949 kinase inhibitors/regulators supplied as pre-dissolved Solutions or Solid

Solution: 3,805 compounds supplied in 10 mM solution, 140 compounds supplied in 2 mM solution, 4 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice