1. NF-κB
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  3. NF-κΒ activator 1

NF-κΒ activator 1 

Cat. No.: HY-134476 Purity: 98.02%
Handling Instructions

NF-κΒ activator 1 is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD)2 mRNA expression.

For research use only. We do not sell to patients.

NF-κΒ activator 1 Chemical Structure

NF-κΒ activator 1 Chemical Structure

CAS No. : 2387524-59-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

NF-κΒ activator 1 is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD)2 mRNA expression[1].

IC50 & Target[1]

NF-κB

0.9 μM (EC50)

In Vitro

NF-κΒ activator 1 (compound 32) (1 μM; 6 hours) induces SOD2 mRNA expression in SH-SY5Y neuroblastoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

314.33

Formula

C₁₆H₁₁FN₂O₂S

CAS No.

2387524-59-4

SMILES

O=C(O)C1=CC=CC(C2=CSC(NC3=CC=CC=C3F)=N2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (397.67 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1814 mL 15.9069 mL 31.8137 mL
5 mM 0.6363 mL 3.1814 mL 6.3627 mL
10 mM 0.3181 mL 1.5907 mL 3.1814 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (6.62 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (6.62 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

NF-κΒ activator 1NF-κBNuclear factor-κBNuclear factor-kappaBSOD2SH-SY5YneuroblastomacellsexpressionInhibitorinhibitorinhibit

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NF-κΒ activator 1
Cat. No.:
HY-134476
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