1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Nicergoline

Nicergoline 

Cat. No.: HY-B0702 Purity: 99.62%
COA Handling Instructions

Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease.

For research use only. We do not sell to patients.

Nicergoline Chemical Structure

Nicergoline Chemical Structure

CAS No. : 27848-84-6

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
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ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 96 In-stock
Estimated Time of Arrival: December 31
100 mg USD 140 In-stock
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Description

Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease[1][2].

IC50 & Target

α1A-adrenoceptor[1]

In Vitro

Nicergoline (0.3-30 μM; 24 h) attenuates activated microglia- and astrocytes-induced neuronal cell death[3].
Nicergoline (0.3-30 μM; 48 h) suppresses the production of proinflammatory cytokines and superoxide anion by activated microglia[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nicergoline (10 mg/kg; i.v. once daily for 60 d) improves impaired neurogenesis and cognitive competence in mice with Alzheimer's disease[2].
Nicergoline (10 mg/kg; i.v. once daily for 60 d) inhibits apoptosis, inflammation and oxidative stress in hippocampal cells, and regulates the activity of hippocampal cells through the PI3K/AKT signaling pathway in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3×Tg-AD mice (male, 28-35 g, 6 weeks) with the Alzheimer's disease[2]
Dosage: 10 mg/kg
Administration: I.v. once daily for 60 days
Result: Improved neurogenesis and cognitive competence.
Decreased the degree of dementia.
Downregulated pathogenic Aβ-42 and -40 peptides and APP in the hippocampi.
Increased Levels of the neuroprotective forkhead box protein P2 (Foxp2), Src homology 2-containing inositol phosphatase (SxIP) and end-binding proteins (EB) in the hippocampi.
Exhibited marked differences in the dispersion of the pyramidal cell layer between the nicergoline-treated and control groups.
Clinical Trial
Molecular Weight

484.39

Formula

C24H26BrN3O3

CAS No.
SMILES

CO[[email protected]@]([[email protected]@]1([H])C2)(C[[email protected]@H](COC(C3=CN=CC(Br)=C3)=O)CN1C)C4=C5C2=CN(C)C5=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0645 mL 10.3223 mL 20.6445 mL
5 mM 0.4129 mL 2.0645 mL 4.1289 mL
10 mM 0.2064 mL 1.0322 mL 2.0645 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.62%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Nicergoline
Cat. No.:
HY-B0702
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