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PLX5622

98 Cited Publications
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Based on 98 publication(s) in Google Scholar

PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 μM; Ki=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. PLX5622 is predominantly administered via ad libitum diets with a dose of 1200 ppm.

For research use only. We do not sell to patients.

  • Purity: 99.79%
  • CAS No.: 1303420-67-8
  • Formula: C21H19F2N5O
  • Molecular Weight:395.41
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • PLX5622 Chemical Structure
    PLX5622 Chemical Structure
  • Experimental Validation Results for PLX5622
  • Experimental Validation Results for PLX5622
  • Experimental Validation Results for PLX5622
  • Experimental Validation Results for PLX5622
  • Experimental Validation Results for PLX5622
  • Experimental Validation Results for PLX5622
  • Experimental Validation Results for PLX5622
CAS No.: 1303420-67-8
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • PLX5622 Chemical Structure
    PLX5622 Chemical Structure
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    MedChemExpress Validation
    PLX5622 were mixed in AIN-76A feed with a dosage of 1200 ppm. C57BL/6 male mice (11-12 weeks) were fed with PLX5622 (1200 ppm) AIN-76A diet ad libitum. Brain tissues were obtained after 7/14 days. The expression of IBA1+ (a marker of microglia) was detected by immunofluorescence. The number of IBA1+ cells was counted using Image J. The results showed that PLX5622 (HY-114153) in AIN-76A Diet (1200 ppm) could effectively eliminate microglias.

  • 1/16

    PLX5622 purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jul;643(8071):509-518. [Abstract]

    Customer Validation
     PLX5622 (1200 ppm; Fed diet). IBA1-expressing microglia/macrophages in the brainstem of Rag2−/− recipients of CD4-tdTomato+ TCR7B8 CD4 T cells 6 to 7 weeks after transfer.

  • 1/16

    PLX5622 purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jul;643(8071):509-518. [Abstract]

    Customer Validation
     PLX5622 (1200 ppm; Fed diet). Neurological score of Csf2-deficient or Csf2-sufficient TCR7B8 transferred hosts with or without CSF1R inhibitor treatment.

  • 1/16

    PLX5622 purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Sep 23. [Abstract]

    Customer Validation
     PLX5622 (1200 mg/kg; Fed diet). MBP immunostaining revealing enhanced white matter repair (reduced MBP+ area loss) in the striatum of PLX-treated MCAO mice compared to vehicle controls.

  • 1/16

    PLX5622 purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Sep 23. [Abstract]

    Customer Validation
     PLX5622 (1200 mg/kg; Fed diet). PLX treatment significantly depleted the microglial population following MCAO. n = 3 mice/group.

  • 1/16

    PLX5622 purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Sep 23. [Abstract]

    Customer Validation
     Efavirenz (EFV) (0.09 mg/kg; i.g.; once daily) treatment significantly downregulated pro-inflammatory transcripts of microglia in MCAO mice.

  • 1/16

    PLX5622 purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Oct 9:S1074-7613(24)00458-8. [Abstract]

    Customer Validation
     PLX5622 (0.12%; Fed diet). Tile scan images and magnified images show MX04 (gray) labeling for plaque visualization in injected areas as well as IBA1 (magenta) and CD68 (cyan) staining.

  • PLX5622