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Cat. No.: HY-P10761A

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NOTA-DPI-4452 TFA

Name: NOTA-DPI-4452 TFA
Brand: MedChemExpress
SKU: HY-P10761A
Price: 460.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

NOTA-DPI-4452 TFA is a trifluoroacetate derivative with DPI-4452 (HY-P10761) as the parent peptide. DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage that can chelate with radionuclides and is used to express CAIX tumors for PET-CT imaging and research.

For research use only. We do not sell to patients.

Purity : 98.53%
Formula: C₈₈H₁₂₅N₂₁O₂₇S₃·xC₂HF₃O₂
Molecular Weight:2005.25 (free base)

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

NOTA-DPI-4452 TFA Chemical Structure

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Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

All Carbonic Anhydrase Isoforms :

In Vitro

NOTA-DPI-4452 TFA is a trifluoroacetate derivative with DPI-4452 (HY-P10761) as the parent peptide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 2005.25 (free base)
Formula C₈₈H₁₂₅N₂₁O₂₇S₃·xC₂HF₃O₂
Color White to off-white
SMILES

C[C@@H](O)[C@H](NC([C@@H](N1)CC(C)C)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](CSCC4=CC(CSC[C@H](NC([C@@H](NC(CN5CCN(C(CN6CCN(CC(O)=O)CCN(CC(O)=O)CC6)=O)CC5)=O)CCC(N)=O)=O)C(N[C@@H](CCC(O)=O)C(N(CCC7)[C@H]7C(N[C@@H](CC(O)=O)C(N[C@@H](CC8=CC=CC(NC(CCCS(=O)(N)=O)=O)=C8)C1=O)=O)=O)=O)=O)=CC=C4)C(N)=O)=O)CO)=O)=O.OC(C(F)(F)F)=O.[x]
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg
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g
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (308 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Massière, et al. Preclinical Characterization of DPI-4452: A68Ga/177Lu Theranostic Ligand for Carbonic Anhydrase IX. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024, 65(5), 761–767. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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