Captan-d6
Based on 1 Customer Validation
Captan-d6 is the deuterated-labeled Captan (HY-B1584). Captan is a thiol-reactive fungicide. Captan irreversibly depletes protein and non-protein thiols (including glutathione), reducing enzyme activity and fungal respiration/metabolism. Captan inhibits DNA synthesis and replication fork progression, and induces ROS accumulation, oxidative stress, inflammation, ER stress, mitochondrial dysfunction, autophagy, DNA damage, and apoptosis as well as loss of membrane integrity with necrosis. Captan is used to control fungal diseases of various fruits, vegetables, and ornamental plants.
For research use only. We do not sell to patients.
- CAS No.: 1330190-00-5
- Formula: C9H2D6Cl3NO2S
- Molecular Weight:306.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- ROS/oxidative-stress fluorescent staining
- Research Protocol for Inflammation-related Diseases
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Mitochondrial membrane-potential and mitochondrial mass staining
- Autophagy
- Apoptosis Solutions
- Lysosome and acidic-vesicle live-cell staining
- Macroautophagy Solutions
- Genotoxicity/Mutagenicity Study
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1330190-00-5
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Unlabeled CAS 133-06-2
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Molecular Weight 306.63
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Formula C9H2D6Cl3NO2S
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SMILES
ClC(Cl)(Cl)SN1C(C2C(C([2H])([2H])C([2H])=C([2H])C2([2H])[2H])C1=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Captan-d6 Related Classifications
HY-B1584S Related Classifications
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Keywords
- Captan-d6
- 1330190-00-5
- Isotope-Labeled Compounds
- Environmental Pollutants
- Fungal
- Apoptosis
- Autophagy
- Environmental Contaminants
- ATR signaling
- DNA polymerase inhibitor
- DNA synthesis
- glutathione
- ovarian dysfunction
- oxidative stress
- reactive oxygen species
- replication fork progression
- replicative stress
- thiol-reactive
- Inhibitor
- inhibitor
- inhibit