Polythiazide
Based on 1 Customer Validation
Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity.
For research use only. We do not sell to patients.
- Purity: 98.63%
- CAS No.: 346-18-9
- Formula: C11H13ClF3N3O4S3
- Molecular Weight:439.88
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Polythiazide (500 μM, 1 min) induces significant phototoxic NHIK 3025 cell death under Bluelight 2000 apparatus (Ex: 325 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Polythiazide (oral administration, 0.4 mg/kg) shows diuretic and saluretic effects in hypertensive dogs and rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cholesterol-fed C57BL/cdJ mice[3]
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Dosage:10 mg/kg
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Administration:Oral gavage, daily for 5 days
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Result:Caused approximately 13% rise in total plasma cholesterol levels, and increased non-HDL lipoprotein fraction.
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Animal Model:Hypertensive dogs[1]
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Dosage:0.4 mg/kg
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Administration:Oral administration, daily for 5 days
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Result:Increased in excretion of sodium and chloride.
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Animal Model:Hypertensive rats[1]
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Dosage:0.05, 0.1, 0.2, 0.4 mg/kg
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Administration:Oral administration, twice a day for 3 days.
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Result:Displayed natriuretic and chloruretic effects.
Chemical Information
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CAS No. 346-18-9
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Appearance Solid
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Molecular Weight 439.88
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Formula C11H13ClF3N3O4S3
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Color White to off-white
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SMILES
O=S(C1=C(Cl)C=C(C2=C1)NC(CSCC(F)(F)F)N(C)S2(=O)=O)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. A SCRIABINE, et al. Pharmacological studies with polythiazide, a new diuretic and antihypertensive agent. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:864-72. [Content Brief]
[2]. E Selvaag, et al. Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model. Photodermatol Photoimmunol Photomed. 1996 Feb;12(1):1-6. [Content Brief]
[3]. M N Krupp, et al. Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdJ mouse. J Cardiovasc Pharmacol. 1989;13 Suppl 2:S11-8; discussion S18-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polythiazide Related Classifications
HY-16403 Related Classifications
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