2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Olaptesed pegol sodium

Olaptesed pegol sodium  (Synonyms: NOX-A12 sodium)

Cat. No.: HY-160041A Purity: 95.94%
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Olaptesed pegol (NOX-A12) sodium is a L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol sodium neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment. Olaptesed pegol sodium can enhances the infiltration of human primary T cells and NK cells and inhibit tumor growth companied with anti-PD-1 antibody. Olaptesed pegol sodium can be used for researches of colon cancer and lymphocytic leukemia.

For research use only. We do not sell to patients.

Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA β-L-(G-C-G-U-G-G-U-G-U-G-A-U-C-U-A-G-A-U-G-U-A-U-U-G-G-C-U-G-A-U-C-C-U-A-G-U-C-A-G-G-U-A-C-G-C) 5′-[6-[[2-[(2-hydroxyacetyl)(2-hydroxyethyl)amino]acetyl]amino]hexyl hydrogen phosphate] (2:1), sodium salt

Olaptesed pegol sodium Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Olaptesed pegol sodium Related Antibodies

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Description

Olaptesed pegol (NOX-A12) sodium is a L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol sodium neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment. Olaptesed pegol sodium can enhances the infiltration of human primary T cells and NK cells and inhibit tumor growth companied with anti-PD-1 antibody. Olaptesed pegol sodium can be used for researches of colon cancer and lymphocytic leukemia[1][2].

IC50 & Target

CXCL12[1]
In Vitro

Olaptesed pegol (10-100 nM, overnight incubation) sodium dose-dependently enhances the infiltration of human primary T cells (CD8+, CD4+) and NK cells in heterotypic tumor-stroma spheroids (PSN-1/MS-5, HT-29/MS-5, H1299/MS-5, U251MG/MS-5) containing CXCL12, slightly promotes B cell infiltration, has no effect on monocyte infiltration, and results in low levels of Treg cell infiltration[2].
Olaptesed pegol (10 nM, combined with anti-PD-1 antibody, overnight incubation) sodium synergizes with anti-PD-1 antibody to enhance the activation of Jurkat PD-1/luc T cells in the MS-5/CHO-PD-L1 spheroid model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olaptesed pegol sodium Related Antibodies
In Vivo

Olaptesed pegol (20 mg/kg, s.c., every other day, initiated on day 5) sodium combined with anti-PD-1 antibody (10 mg/kg, intraperitoneal injection, twice weekly, initiated on day 7) significantly inhibits tumor growth in BALB/c mice bearing CT-26 colorectal cancer syngeneic tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice bearing CT-26 colorectal cancer syngeneic tumors[2]
Dosage: 20 mg/kg
Administration: Subcutaneously injection, every other day, initiated on day 5
Result: Inhibited tumor growth with 5 out of 8 mice responding.
Olaptesed pegol alone had no significant inhibitory effect on tumor growth.
Clinical Trial
Molecular Weight

54656.69 (free acid)

Appearance

Solid

Color

White to off-white

SMILES

[Olaptesed pegol (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

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References
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Olaptesed pegol sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olaptesed pegolNOX-A12CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsPEGylated constructsL-oligonucleotidesaptamersInhibitorinhibitorinhibit

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