2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK Stem Cell/Wnt
  3. Casein Kinase DYRK
  4. ON 108600

ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity.

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ON 108600

ON 108600 화학구조

CAS No. : 1585246-23-6

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

ON 108600 Related Antibodies

Top Publications Citing Use of Products

View All Casein Kinase Isoform Specific Products:

View All Isoforms
CK1 CK2

View All DYRK Isoform Specific Products:

View All Isoforms
DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity[1].

IC50 & Target

DYRK2

0.028 μM (IC50)

DYRK1A

0.016 μM (IC50)

DYRK1B

0.007 μM (IC50)

CK2α2

0.005 μM (IC50)

CK2α1

0.05 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HT-22 IC50
1 μM
Compound: 29; 108600
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 36876904]
분자량

537.39

화학식

C22H14Cl2N2O6S2
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

ClC(C=CC=C1Cl)=C1CS(=O)(C2=CC=C(S/C(C(N3)=O)=C\C4=CC([N+]([O-])=O)=C(C=C4)O)C3=C2)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (186.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8608 mL 9.3042 mL 18.6085 mL
5 mM 0.3722 mL 1.8608 mL 3.7217 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8608 mL 9.3042 mL 18.6085 mL 46.5211 mL
5 mM 0.3722 mL 1.8608 mL 3.7217 mL 9.3042 mL
10 mM 0.1861 mL 0.9304 mL 1.8608 mL 4.6521 mL
15 mM 0.1241 mL 0.6203 mL 1.2406 mL 3.1014 mL
20 mM 0.0930 mL 0.4652 mL 0.9304 mL 2.3261 mL
25 mM 0.0744 mL 0.3722 mL 0.7443 mL 1.8608 mL
30 mM 0.0620 mL 0.3101 mL 0.6203 mL 1.5507 mL
40 mM 0.0465 mL 0.2326 mL 0.4652 mL 1.1630 mL
50 mM 0.0372 mL 0.1861 mL 0.3722 mL 0.9304 mL
60 mM 0.0310 mL 0.1551 mL 0.3101 mL 0.7754 mL
80 mM 0.0233 mL 0.1163 mL 0.2326 mL 0.5815 mL
100 mM 0.0186 mL 0.0930 mL 0.1861 mL 0.4652 mL
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ON 108600 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ON 1086001585246-23-6ON108600ON-108600Casein KinaseDYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseCasein Kinase/DYRK/TNIK InhibitorTriple negative breast cancer (TNBC)?Inhibitorinhibitorinhibit

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상품명:
ON 108600
Cat. No.:
HY-156816
수량:
MCE Japan Authorized Agent:

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