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Cat. No.: HY-186303

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Onzotrigine

Name: Onzotrigine
Brand: MedChemExpress
SKU: HY-186303
Availability: PreOrder

(Synonyms: LTG-001)

Onzotrigine (LTG-001) is a potent, selective, voltage-gated sodium channel Nav1.8 inhibitor. Onzotrigine may be used in pain-related research.

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CAS No.: 2834099-10-2
Formule: C₂₁H₁₈F₄N₄O₃S
Masse moléculaire:482.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Onzotrigine Chemical Structure

CAS No.: 2834099-10-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Onzotrigine (LTG-001) is a potent, selective, voltage-gated sodium channel Nav1.8 inhibitor. Onzotrigine may be used in pain-related research^[1].

IC₅₀ & Target^[1]

Nav1.8

Voir tous les produits spécifiques à Isoform Sodium Channel :

In Vivo

Onzotrigine (LTG-001) (low dose: 300 mg loading dose, followed by 150 mg every 12 hours; high dose: 450 mg loading dose, followed by 300 mg every 12 hours; 48 hours) showed superior analgesia to placebo for moderate to severe postoperative pain after abdominoplasty, as evidenced by higher SPID48 values^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2834099-10-2
Masse moléculaire 482.45
Formule C₂₁H₁₈F₄N₄O₃S
SMILES

C[S@@](C1=CC=CC(NC(C2=C(N=CC(C(F)(F)F)=C2C)OC3=C(N=C(C=C3)F)C)=O)=C1)(=N)=O
Synonyms

LTG-001
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Singla N, et al. Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain. N Engl J Med. 2026 Jul 30;395(5):454-464.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références

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Onzotrigine

Voir tous les produits spécifiques à Isoform Sodium Channel