Simaroubaceae Extract

Kumunorquassin C is a tirucallane-type nortriterpenoid that can be found in the leaves of Picrasma quassioides.

16α-O-Methylneoquassin is a natural diterpene.

Quassidine B (Dihydropicrasidine A) is a natural alkaloid.

16α-O-Ethylneoquassin is a natural diterpene.

16β-O-Methylneoquassin is a natural diterpene.

16-β-O-Ethylneoquassin is a natural diterpene.

Picrasinol B is a natural diterpene.

Picrasidine A is an active compound that can be extracted from the natural product Picrasma quassioides (D. Don) Benn. Picrasidine A has the potential to prevent UVB-induced reactive oxygen species (ROS) generation.

Picrasidine J is a selective inhibitor targeting the KLK-10 protease and the ERK signaling pathway. Picrasidine J inhibits epithelial-mesenchymal transition (EMT) by upregulating E-Cadherin and ZO-1 and downregulating β-catenin and Snail, while simultaneously reducing KLK-10 expression and inhibiting ERK phosphorylation, thereby exhibiting significant anti-migratory and anti-invasive activity. Picrasidine J can inhibit the metastasis of head and neck squamous cell carcinoma (HNSCC) and is primarily used in anti-metastasis research for head and neck tumors.

Bruceoside D is a cytotoxic quassinoid glucoside found in Brucea javanica. Bruceoside D is a microtubule polymerization inhibitor. Bruceoside D demonstrates inhibitory activity against leukemia (CCRF-CEM), non-small cell lung cancer (A549), and ovarian cancer (OVCAR-3) cell lines. Bruceoside D is promising for research of cancers.

Yadanzigan (YDZG) is an anti-inflammatory agent and a NLRP3 inhibitor. Yadanzigan specifically inhibits NLRP3 activation via inhibiting NF-κB pathway and Reactive Oxygen Species production. Yadanzigan also moderates LPS (HY-D1056)-induced acute lung injury (ALI) in mice.

Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC₅₀ of 14.21 μM.

9,10-Dimethoxycanthin-6-one is an alkaloid compound. 9,10-Dimethoxycanthin-6-one exhibits NF-κB inhibitory effects with an IC₅₀ of 19.5 μM.

Semialactone is a triterpenes, which can be isolated from Rhus javanica.

Yadanzioside G is a glucoside that can be isolated from Brucu javanica.

Dehydrobruceantin has potential antileukemic activity.

Yadanzioside P is an antileukemic quassinoid glycoside. Yadanzioside P can be isolated from the seeds of Brucea javanica (L.). Yadanzioside P can be used for the research of cancer.

Dehydrobruceantinol is a natural product that can be isolated from Brucea javanica.

1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia.

Bruceantinol A, a natural compound, can be isolated from Brucea javanica seeds.