Otlertuzumab
Based on 1 Customer Validation
Otlertuzumab (TRU-016) is a humanized anti-CD37 monoclonal antibody that can be used for cancer research.
For research use only. We do not sell to patients.
- Purity: 99.00%
- CAS No.: 1372645-37-8
- Molecular Weight:104.8093 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
[(scFv-heavy-kappa)G1-h-CH2-CH3]2
Human
TSPAN26/CD37
Otlertuzumab (TRU-016) in combination with Rituximab (HY-P9913), Rapamycin (HY-10219), or Bendamustine (HY-13567) increases cell killing of NHL cells[2].
Otlertuzumab has the ability to bind to and kill CD37+ cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Otlertuzumab shows significant antitumor activity in mice bearing Ramos or Daudi tumor xenografts[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[(scFv-heavy-kappa)G1-h-CH2-CH3]2
ELISA, FACS, Functional assay
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Immobilized CD37 Protein, Human can bind Otlertuzumab. The EC50 for this effect is 37.2 ng/mL. -
Flow Cytometry analysis of Raji cells labelling TSPAN26/CD37 (red) with Otlertuzumab (anti-TSPAN26/CD37) (HY-P99212). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 1372645-37-8
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Appearance Liquid
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Molecular Weight 104.8093 kDa
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Color Colorless to light yellow
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SMILES
[Otlertuzumab]
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Synonyms
TRU-016
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)