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Cat. No.: HY-147343

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P300-IN-2

P300-IN-2 is a p300 inhibitor (IC₅₀=3.6 μM) that inhibits histone acetyltransferase p300 activity. P300-IN-2 shows weak inhibitory activity against CWR22RV1 cell proliferation. P300-IN-2 can be used for research on p300-mediated diseases, such as cancer.

For research use only. We do not sell to patients.

CAS No.: 2488867-43-0
Formula: C₂₆H₂₇FN₄O₅
Molecular Weight:494.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

P300-IN-2 Chemical Structure

CAS No.: 2488867-43-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target

^[1]

p300

3.6 μM (IC₅₀)

All Histone Acetyltransferase Isoforms :

In Vitro

P300-IN-2 (compound 17) shows weak inhibitory activity against CWR22RV1 cell proliferation, with an IC₅₀ > 2000 nM^[1].

P300-IN-2 inhibits the histone acetyltransferase p300 with an IC₅₀ of 3.6 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2488867-43-0
Molecular Weight 494.52
Formula C₂₆H₂₇FN₄O₅
SMILES

O=C1[C@@]2(C=3C(CC2)=CC(NC(NC)=O)=CC3)OC(=O)N1CC(=O)N4[C@H](CC[C@H]4C)C5=CC=C(F)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fan L, et al. Histone acetylase p300 inhibitor and application thereof. CN111217802A, 2020.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
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P300-IN-2

All Histone Acetyltransferase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

P300-IN-2 Related Classifications

HY-147343 Related Classifications

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