2. Cytoskeleton Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. Microtubule/Tubulin Drug-Linker Conjugates for ADC
  4. PEG4-aminooxy-MMAF

PEG4-aminooxy-MMAF  (Synonyms: Amberstatin; AS269)

Cat. No.: HY-128968 Purity: 99.83%
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PEG4-aminooxy-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the potent antitubulin agent MMAF, linked via the noncleavable PEG4.

For research use only. We do not sell to patients.

PEG4-aminooxy-MMAF Chemical Structure

PEG4-aminooxy-MMAF Chemical Structure

CAS No. : 1415246-35-3

Size Price Stock Quantity
5 mg USD 660 In-stock
10 mg USD 1050 Get quote
50 mg USD 2650 Get quote
100 mg USD 4200 Get quote
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

PEG4-aminooxy-MMAF Related Antibodies

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View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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  • Purity & Documentation

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Description

PEG4-aminooxy-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the potent antitubulin agent MMAF, linked via the noncleavable PEG4[1].

IC50 & Target

Auristatin

 

Molecular Weight

923.19

Formula

C47H82N6O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCOCCOCCOCCON)=O)=O)=O)OC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (108.32 mM)

DMSO : 100 mg/mL (108.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0832 mL 5.4160 mL 10.8320 mL
5 mM 0.2166 mL 1.0832 mL 2.1664 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (2.71 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (2.71 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.0832 mL 5.4160 mL 10.8320 mL 27.0800 mL
5 mM 0.2166 mL 1.0832 mL 2.1664 mL 5.4160 mL
10 mM 0.1083 mL 0.5416 mL 1.0832 mL 2.7080 mL
15 mM 0.0722 mL 0.3611 mL 0.7221 mL 1.8053 mL
20 mM 0.0542 mL 0.2708 mL 0.5416 mL 1.3540 mL
25 mM 0.0433 mL 0.2166 mL 0.4333 mL 1.0832 mL
30 mM 0.0361 mL 0.1805 mL 0.3611 mL 0.9027 mL
40 mM 0.0271 mL 0.1354 mL 0.2708 mL 0.6770 mL
50 mM 0.0217 mL 0.1083 mL 0.2166 mL 0.5416 mL
60 mM 0.0181 mL 0.0903 mL 0.1805 mL 0.4513 mL
80 mM 0.0135 mL 0.0677 mL 0.1354 mL 0.3385 mL
100 mM 0.0108 mL 0.0542 mL 0.1083 mL 0.2708 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PEG4-aminooxy-MMAF Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEG4-aminooxy-MMAF1415246-35-3Amberstatin AS269AS269AS 269AS-269Microtubule/TubulinDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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