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Cat. No.: HY-169993A

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Pevifoscorvir

Name: Pevifoscorvir
Brand: MedChemExpress
SKU: HY-169993A
Availability: PreOrder

(Synonyms: ALG-000184 free acid)

Pevifoscorvir (ALG-000184 (free acid)) is an orally active inhibitor of hepatitis B virus (HBV), and it is also a prodrug of ALG-001075 (HY-177022). Pevifoscorvir can inhibit the production of HBV DNA in liver cells. Pevifoscorvir can be used in the research of chronic hepatitis B.

For research use only. We do not sell to patients.

CAS No.: 2495324-71-3
Formula: C₂₃H₂₂FN₄O₈P
Molecular Weight:532.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pevifoscorvir Chemical Structure

CAS No.: 2495324-71-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

Pevifoscorvir (ALG-000184 (free acid)) (3 days) can effectively inhibit the production of HBV DNA in HepG2.117 cells, with its EC₅₀ being 1.45 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pevifoscorvir (ALG-000184 (free acid)) (10-30 mg/kg; p.o.; single dose) when administered orally to rats and dogs, will be completely converted into ALG-001075, resulting in a higher exposure of ALG-001075 in the liver and a 50 or 12-fold higher systemic exposure of ALG-001075 compared to direct administration of ALG-001075^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2495324-71-3
Molecular Weight 532.41
Formula C₂₃H₂₂FN₄O₈P
SMILES

N#CC1=CC(NC(C2=C(C)C(C(C(N(C3(COC3)C#C)COP(O)(O)=O)=O)=O)=C(C)N2C)=O)=CC=C1F
Synonyms

ALG-000184 free acid
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sandrine Vendeville, et al. The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075. J Med Chem. 2024 Dec 12;67(23):21126-21142. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Pevifoscorvir

All DNA/RNA Synthesis Isoforms