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Art. -Nr.: HY-N13095

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(+)-Plakevulin A

(+)-Plakevulin A (Plakevulin A) is an oxylipin and can be isolated from an Okinawan sponge Plakortis sp. (+)-Plakevulin A inhibits the enzymatic activity of DNA polymerases α and δ. (+)-Plakevulin A induces apoptosis and shows anticancer activity.

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CAS. Nr.: 518035-27-3
Formel: C₂₃H₄₂O₄
Molecular Weight:382.58

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

(+)-Plakevulin A Chemical Structure

CAS. Nr.: 518035-27-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

DNA Polymerase

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	11.5 μM Compound: (+)-1	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]
HL-60	IC₅₀	2.02 μM Compound: (+)-1	Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]
HL-60	IC₅₀	2.63 μM Compound: (+)-1	Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 48 hrs by WST-8 assay Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 48 hrs by WST-8 assay	[PMID: 38996938]
MC3T3-E1	IC₅₀	12.38 μM Compound: (+)-1	Cytotoxicity against mouse MC3T3-E1 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse MC3T3-E1 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]
MRC5	IC₅₀	>15 μM Compound: (+)-1	Cytotoxicity against human MRC5 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]

Chemical Information

CAS. Nr. 518035-27-3
Molecular Weight 382.58
Formel C₂₃H₄₂O₄
SMILES

COC([C@H]1[C@@](O)(C=C[C@@H]1O)CCCCCCCCCCCCCCCC)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Animals
Okinawan sponge Plakortis sp.
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kabasawa M, et al . Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells. Bioorg Med Chem Lett. 2024 Sep 15;110:129886. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
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(+)-Plakevulin A

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

(+)-Plakevulin A Related Classifications

HY-N13095 Related Classifications