country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-163892

Copy Link Print Information

POLRMT-IN-1

POLRMT-IN-1 (compound S7) is a POLRMT inhibitor. POLRMT-IN-1 can be used in cancer-related research.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₄FNO₄
Molecular Weight:397.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

POLRMT-IN-1 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

POLRMT-IN-1 (compound S7) is a POLRMT inhibitor. POLRMT-IN-1 can be used in cancer-related research^[1].

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CAPAN-1	IC₅₀	0.404 μM Compound: S7	Antiproliferative activity against human CAPAN-1 cells assessed as cell viability measured after 168 hrs incubation by SRB assay Antiproliferative activity against human CAPAN-1 cells assessed as cell viability measured after 168 hrs incubation by SRB assay	[PMID: 39049433]
HUVEC	IC₅₀	>50 μM Compound: S7	Antiproliferative activity against HUVEC cells assessed as cell viability measured after 168 hrs incubation by SRB assay Antiproliferative activity against HUVEC cells assessed as cell viability measured after 168 hrs incubation by SRB assay	[PMID: 39049433]
MIA PaCa-2	IC₅₀	0.005 μM Compound: S7	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell viability measured after 168 hrs incubation by SRB assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell viability measured after 168 hrs incubation by SRB assay	[PMID: 39049433]
PANC-1	IC₅₀	0.198 μM Compound: S7	Antiproliferative activity against human PANC-1 cells assessed as cell viability measured after 168 hrs incubation by SRB assay Antiproliferative activity against human PANC-1 cells assessed as cell viability measured after 168 hrs incubation by SRB assay	[PMID: 39049433]

Chemical Information

Molecular Weight 397.44
Formula C₂₃H₂₄FNO₄
SMILES

CC1=CC=CC=C1C(C2=C(C=C(C(F)=C2)O[C@@H](C(N(CC)CC)=O)C)O3)=CC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou S,et al. Identification of 6-Fluorine-Substituted Coumarin Analogues as POLRMT Inhibitors with High Potency and Safety for Treatment of Pancreatic Cancer. J Med Chem. 2024 Jul 24. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Biological Activity
- Description
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

POLRMT-IN-1

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

POLRMT-IN-1 Related Classifications

HY-163892 Related Classifications