FGF-8
FGF-8 is a developmental organizer rather than a routine mitogen. Multiple isoforms generated by alternative splicing and alternative translation initiation signal chiefly through FGFR1c, FGFR3c and FGFR4c. FGF-8 patterns the midbrain-hindbrain boundary from the isthmic organizer, directs limb-bud outgrowth, controls the migration of gonadotropin-releasing hormone neurons and participates in cardiac and pharyngeal development. In humans, FGF8 mutations cause hypogonadotropic hypogonadism with or without cleft lip and palate and have been linked to holoprosencephaly. Recombinant FGF-8b and other isoforms are standard tools for organoid patterning, dopaminergic neuron differentiation protocols and limb and neural development assays.
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FGF-8 Recombinant Proteins (11)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
