(Rac)-PDE4-IN-4
(Rac)-PDE4-IN-4 is the diastereomer mixture of PDE4-IN-4 (HY-115871). PDE4-IN-4 is a dual M3 (pIC50 = 10.2) antagonist-PDE4 (pIC50 = 8.8) inhibitor for the inhaled research of pulmonary diseases.
For research use only. We do not sell to patients.
- Formula: C36H37Cl2N3O7S
- Molecular Weight:726.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Eosinophil | ED50 |
30 nmol/Kg
Compound: 92a
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Antiinflammatory activity in ovalbumin induced Brown Norway rat airway inflammation model assessed as reduction in eosinophil counts in bronchoalveolar lavage administered via inhalation for 3 consecutive days and measured after 24 hrs post last dose
Antiinflammatory activity in ovalbumin induced Brown Norway rat airway inflammation model assessed as reduction in eosinophil counts in bronchoalveolar lavage administered via inhalation for 3 consecutive days and measured after 24 hrs post last dose
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[PMID: 34142835] |
Chemical Information
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Molecular Weight 726.67
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Formula C36H37Cl2N3O7S
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SMILES
O=C(C1=CC=C(CNC(C2=CC=CC=C2)C(O[C@H]3CN4CCC3CC4)=O)S1)O[C@H](C5=CC=C(OC)C(OC)=C5)CC6=C(Cl)C=[N+]([O-])C=C6Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-PDE4-IN-4 Related Classifications
HY-115871A Related Classifications
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