(Rac)-PDE4-IN-4

Cat. No.: HY-115871A: Data Sheet Handling Instructions
FAQs
Technical Support

(Rac)-PDE4-IN-4 is the diastereomer mixture of PDE4-IN-4 (HY-115871). PDE4-IN-4 is a dual M3 (pIC₅₀ = 10.2) antagonist-PDE4 (pIC₅₀ = 8.8) inhibitor for the inhaled research of pulmonary diseases.

For research use only. We do not sell to patients.

(Rac)-PDE4-IN-4 Chemical Structure

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MOQ		Minimum order quantity
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This product is a controlled substance and not for sale in your territory.

Other Forms of (Rac)-PDE4-IN-4:

PDE4-IN-4 Get quote

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•Related Small Molecules:

•Related Proteins:

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

View All mAChR Isoform Specific Products:

View All Isoforms

mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Eosinophil	ED₅₀	30 nmol/Kg Compound: 92a	Antiinflammatory activity in ovalbumin induced Brown Norway rat airway inflammation model assessed as reduction in eosinophil counts in bronchoalveolar lavage administered via inhalation for 3 consecutive days and measured after 24 hrs post last dose Antiinflammatory activity in ovalbumin induced Brown Norway rat airway inflammation model assessed as reduction in eosinophil counts in bronchoalveolar lavage administered via inhalation for 3 consecutive days and measured after 24 hrs post last dose	[PMID: 34142835]

Molecular Weight

726.67

Formula

C₃₆H₃₇Cl₂N₃O₇S

SMILES

O=C(C1=CC=C(CNC(C2=CC=CC=C2)C(O[C@H]3CN4CCC3CC4)=O)S1)O[C@H](C5=CC=C(OC)C(OC)=C5)CC6=C(Cl)C=[N+]([O-])C=C6Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Armani E, et al. Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2021;64(13):9100-9119. [Content Brief]

(Rac)-PDE4-IN-4 Related Classifications

Others

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-PDE4-IN-4Phosphodiesterase (PDE)mAChRMuscarinic acetylcholine receptordiastereomerPDE4-IN-4Inhibitorinhibitorinhibit

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