RAF-IN-4
RAF-IN-4 (Compound 120) is a Raf Kinase inhibitor. RAF-IN-4 shows IC50 values of 134.3, 118.6 and 276.7 nM for B-Raf, B-Raf (V600E) and C-Raf. RAF-IN-4 can inhibit the proliferation of cancer cells by blocking the Raf signaling pathway. RAF-IN-4 can be used for research of cancer, such as lung cancer and breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 1445582-05-7
- Formula: C23H18N4O2S
- Molecular Weight:414.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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B-Raf 134.3 nM (IC50) |
BRafV600E 118.6 nM (IC50) |
C-Raf 276.7 nM (IC50) |
RAF-IN-4 inhibits A549, A375, MDA-MB-231 and COLO2OS cells proliferation with IC50 values of 12.1, 8.5, 10.9 and 7.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1445582-05-7
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Molecular Weight 414.48
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Formula C23H18N4O2S
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SMILES
O=S(=O)(C=1C=CC(=CC1)C2=CC=C3N=CC=C(NC=4C=CC=C5NN=CC54)C3=C2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RAF-IN-4 Related Classifications
HY-177946 Related Classifications
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