2. MAPK/ERK Pathway
  3. Raf
  4. RAF-IN-4

RAF-IN-4 (Compound 120) is a Raf Kinase inhibitor. RAF-IN-4 shows IC50 values of 134.3, 118.6 and 276.7 nM for B-Raf, B-Raf (V600E) and C-Raf. RAF-IN-4 can inhibit the proliferation of cancer cells by blocking the Raf signaling pathway. RAF-IN-4 can be used for research of cancer, such as lung cancer and breast cancer.

For research use only. We do not sell to patients.

RAF-IN-4

RAF-IN-4 Chemical Structure

CAS No. : 1445582-05-7

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RAF-IN-4 Related Antibodies

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Description

RAF-IN-4 (Compound 120) is a Raf Kinase inhibitor. RAF-IN-4 shows IC50 values of 134.3, 118.6 and 276.7 nM for B-Raf, B-Raf (V600E) and C-Raf. RAF-IN-4 can inhibit the proliferation of cancer cells by blocking the Raf signaling pathway. RAF-IN-4 can be used for research of cancer, such as lung cancer and breast cancer[1].

IC50 & Target[1]

B-Raf

134.3 nM (IC50)

BRafV600E

118.6 nM (IC50)

C-Raf

276.7 nM (IC50)

In Vitro

RAF-IN-4 inhibits A549, A375, MDA-MB-231 and COLO2OS cells proliferation with IC50 values of 12.1, 8.5, 10.9 and 7.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RAF-IN-4 Related Antibodies
Molecular Weight

414.48

Formula

C23H18N4O2S
CAS No.
SMILES

O=S(=O)(C=1C=CC(=CC1)C2=CC=C3N=CC=C(NC=4C=CC=C5NN=CC54)C3=C2)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RAF-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RAF-IN-41445582-05-7RafRaf kinasesInhibitorinhibitorinhibit

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RAF-IN-4
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