Rhodomollein XI
Rhodomollein XI is a naturally occurring grayanane diterpenoid with anti-inflammatory and analgesic activities. Rhodomollein XI inhibits LPS-induced NO production in RAW264.7 mouse macrophages. Rhodomollein XI exhibits analgesic effects in the mouse acetic acid-induced writhing test. Rhodomollein XI can be used for pain- and inflammation-related research.
For research use only. We do not sell to patients.
- CAS No.: 798558-82-4
- Formula: C22H36O8
- Molecular Weight:428.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
9.3 μM
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Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 mouse macrophages.
Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 mouse macrophages.
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29272126 |
In Vitro
Rhodomollein XI (compound 25) exhibits significant inhibitory activity against LPS-induced NO production in RAW264.7 mouse macrophages, with an IC50 of 9.3 μM, and shows no cytotoxicity at 200 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 798558-82-4
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Molecular Weight 428.52
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Formula C22H36O8
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SMILES
O[C@H]1[C@@]23[C@](CC[C@@]1([H])[C@](O)(C3)C)([H])[C@@](O)([C@@]4([H])[C@]([C@@H](C2)OC(C)=O)(C(C)([C@H]([C@@H]4O)O)C)O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rhodomollein XI Related Classifications
HY-N21746 Related Classifications
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Keywords
- Rhodomollein XI
- 798558-82-4
- NO Synthase
- TRPV1/TRPA1 antagonist
- PTP1B inhibitor
- lipopolysaccharide-induced
- acetic acid-induced writhing test
- RAW264.7 mouse macrophages
- AITC-induced nociceptive responses
- capsaicin-induced nociceptive signaling
- antinociceptive
- grayanane diterpenoid
- nitric oxide production
- Inhibitor
- inhibitor
- inhibit