Ro 23-9424
Ro 23-9424 is a broad-spectrum cephalosporin composed of a cephalosporin and a quinolone moiety. Ro 23-9424 shows antimicrobial activity in vivo and in vitro.
For research use only. We do not sell to patients.
- CAS No.: 115622-58-7
- Formula: C31H31F3N8O8S2
- Molecular Weight:764.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
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Quinolone |
Chemical Information
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CAS No. 115622-58-7
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Molecular Weight 764.75
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Formula C31H31F3N8O8S2
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SMILES
O=C(C(N12)=C(COC(C3=CN(CCF)C4=C(C=C(F)C(N5CCN(C)CC5)=C4F)C3=O)=O)CS[C@]2([H])[C@H](NC(/C(C6=CSC(N)=N6)=N\OC)=O)C1=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
[1]. Pfaller MA, et al. RO 23-9424, a new cephalosporin 3'-quinolone: in-vitro antimicrobial activity and tentative disc diffusion interpretive criteria. J Antimicrob Chemother. 1993;31(1):81-88. [Content Brief]
[2]. Christenson JG, et al. Pharmacokinetics of Ro 23-9424, a dual-action cephalosporin, in animals. Antimicrob Agents Chemother. 1990;34(10):1895-1900. [Content Brief]
[3]. Matera G, et al. Effect of RO 23-9424, cefotaxime and fleroxacin on functions of human polymorphonuclear cells and cytokine production by human monocytes. J Antimicrob Chemother. 1996;38(5):799-807. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ro 23-9424 Related Classifications
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