D15
Based on 1 Customer Validation
D15, a peptide with 15 aa segment of dynamin, is an AMPAR endocytosis inhibitor. D15 blocks the interaction of dynamin with amphiphysin 1 and 2. D15 significantly increases AMPAR excitatory postsynaptic potential (EPSC) amplitude of medium spiny neurons (MSNs) in Sapap3 KO mice. D15 can be used for neuropsychiatric disorder research.
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 251939-41-0
- Formula: C69H111N23O19
- Molecular Weight:1566.76
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All iGluR Isoforms
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Biological Activity
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AMPA Receptor |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 251939-41-0
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Appearance Solid
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Molecular Weight 1566.76
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Formula C69H111N23O19
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Color White to off-white
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Synonyms
Dynamin II (828–842)
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Sequence
Pro-Pro-Pro-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-Pro-Gly
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Sequence Shortening
PPPQVPSRPNRAPPG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (63.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6383 mL | 3.1913 mL | 6.3826 mL | 15.9565 mL |
| 5 mM | 0.1277 mL | 0.6383 mL | 1.2765 mL | 3.1913 mL | |
| 10 mM | 0.0638 mL | 0.3191 mL | 0.6383 mL | 1.5956 mL | |
| 15 mM | 0.0426 mL | 0.2128 mL | 0.4255 mL | 1.0638 mL | |
| 20 mM | 0.0319 mL | 0.1596 mL | 0.3191 mL | 0.7978 mL | |
| 25 mM | 0.0255 mL | 0.1277 mL | 0.2553 mL | 0.6383 mL | |
| 30 mM | 0.0213 mL | 0.1064 mL | 0.2128 mL | 0.5319 mL | |
| 40 mM | 0.0160 mL | 0.0798 mL | 0.1596 mL | 0.3989 mL | |
| 50 mM | 0.0128 mL | 0.0638 mL | 0.1277 mL | 0.3191 mL | |
| 60 mM | 0.0106 mL | 0.0532 mL | 0.1064 mL | 0.2659 mL |
D15 Related Classifications
HY-P1386 Related Classifications
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