DS69910557
Based on 1 Customer Validation
DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.
For research use only. We do not sell to patients.
- Purity: 98.86%
- CAS No.: 3032750-17-4
- Formula: C32H33Cl2FN4O3
- Molecular Weight:611.53
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
GPCR/G Protein Compound Library
HY-L006
-
Anti-Cancer Compound Library
HY-L025
-
Endocrinology Compound Library
HY-L047
-
Orally Active Compound Library
HY-L061
-
Osteogenesis Compound Library
HY-L131
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
Biological Activity
IC50: 0.08 μM (PTHR1)[1].
DS69910557 (compound 19e) has highly potent antagonistic activity for PTHR1 with an IC50 value of 0.08 μM[1].
DS69910557 (3 μM) exhibits excellent selectivity against human ether-a-go-go-related-gene (hERG) channel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rats[1]
-
Dosage:5mg/kg
-
Administration:PO
-
Result:Showed excellent PK profile, high maximum plasma concentration and plasma exposure in rats.
Chemical Information
-
CAS No. 3032750-17-4
-
Appearance Solid
-
Molecular Weight 611.53
-
Formula C32H33Cl2FN4O3
-
Color Off-white to light yellow
-
SMILES
ClC(C=N1)=CC(C2=C(C=C(Cl)C=C2)N3C4=CC=C(N5CC(F)(CN[C@@H]6CC[C@@H](C(O)=O)CC6)C5)C=C4)=C1C(C)(C)C3=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (163.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (280 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6352 mL | 8.1762 mL | 16.3524 mL | 40.8811 mL |
| 5 mM | 0.3270 mL | 1.6352 mL | 3.2705 mL | 8.1762 mL | |
| 10 mM | 0.1635 mL | 0.8176 mL | 1.6352 mL | 4.0881 mL | |
| 15 mM | 0.1090 mL | 0.5451 mL | 1.0902 mL | 2.7254 mL | |
| 20 mM | 0.0818 mL | 0.4088 mL | 0.8176 mL | 2.0441 mL | |
| 25 mM | 0.0654 mL | 0.3270 mL | 0.6541 mL | 1.6352 mL | |
| 30 mM | 0.0545 mL | 0.2725 mL | 0.5451 mL | 1.3627 mL | |
| 40 mM | 0.0409 mL | 0.2044 mL | 0.4088 mL | 1.0220 mL | |
| 50 mM | 0.0327 mL | 0.1635 mL | 0.3270 mL | 0.8176 mL | |
| 60 mM | 0.0273 mL | 0.1363 mL | 0.2725 mL | 0.6814 mL | |
| 80 mM | 0.0204 mL | 0.1022 mL | 0.2044 mL | 0.5110 mL | |
| 100 mM | 0.0164 mL | 0.0818 mL | 0.1635 mL | 0.4088 mL |
DS69910557 Related Classifications
HY-148350 Related Classifications
Powered by Bioz