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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
126 Results for "
TCR
" in MedChemExpress (MCE) Product Catalog:
Products (126)
126 Results for "TCR" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: α-GalCer; KRN7000
Research Areas:
α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor) .
4
4 Cited Publications
Cat. No.: HY-P99129
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3
3 Cited Publications
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AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
3
3 Cited Publications
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AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
2
2 Cited Publications
Cat. No.: HY-P5411
CAS No.: 148274-88-8
Synonyms: SIITFEKL, OVA (257-264) Variant
OVA-T4 Peptide (SIITFEKL; OVA (257-264) Variant) is a modified peptide ligand of OVA 257-264 that binds to mouse OT-I TCR with Kd = 1.22 μM, acts as a weaker agonist than the parental N4 peptide to modulate the strength of antigen-presenting cell-T lymphocyte interactions, and alters the amplitude of cytokine responses and NFAT1, p-Erk, and NF-κB signaling responses. OVA-T4 Peptide can be used for research on colon cancer and ovarian cancer .
1
1 Cited Publications
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Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. Cbl-b-IN-1 can promote the secretion of cytokines such as IL-2, IFN-γ, and TNF-α, facilitate T cell activation, and enhance the TCR signaling pathway. Cbl-b-IN-1 can be used in research on immunomodulation .
1
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TCRS-417 (T417) is a small-molecular inhibitor for PBX1. TCRS-417 can directly block PBX1-binding to DNA (IC50 = 6.58 μM), and affects PBX1 transcription. TCRS-417 is able to hammer out the stemness traits of Carboplatin (HY-17393)-resistant (CR) cells to revert to a differentiated status through tacking PBX1 signaling cascade. TCRS-417 significantly suppresses self-renewal and proliferation of cancer cells expressing high levels of PBX1. TCRS-417 can decrease the mRNA levels of FOXM1, NEK2, and E2F2 in cancer cell lines. TCRS-417 is selectively toxic against chr1q-amp myeloma and solid tumor cells .
1
1 Cited Publications
Cat. No.: HY-P70601
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGRT; Major Histocompatibility Complex Class I-Like Fc Receptor; Fc Gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal Fragment Crystallizable Fc Receptor FcRn; IgG Fc Fragment Receptor Transporter Alpha Chain; Immunoglobulin Receptor, Intestinal, Heavy Chain; IgG Receptor FcRn Large Subunit P51; Neonatal Fc-Receptor For Ig; FcgammaRn; FCRN Alpha-Chain; Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor; FcRn Alpha Chain; Transmembrane Alpha Chain Of The Neonatal Receptor; Alpha-Chain; Fc Fragment Of IgG, Receptor, Transporter, Alpha; FCRN; Fc Fragment Of IgG Receptor And Transporter; B2M; Beta 2-Microglobulin; Beta-2-Microglobulin; Beta-2-Microglobin; Beta Chain Of MHC Class I Molecules; AMYLD6; Beta 2-Microglobulin Protein; MHC1D4; Human Nkt TCR Alpha Chain; IMD43; Human Nkt TCR Beta Chain
Species:
Human
Source:
HEK293
Cat. No.: HY-P99339
CAS No.: 1874157-95-5
Synonyms: IMCgp100
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Cat. No.: HY-P990717
CAS No.: 2736407-54-6
Synonyms: IMC-F106C
Synonyms: Ac-6-FP
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Acetyl-6-formylpterin (Ac-6-FP) is a hapten that stabilizes MR1 on antigen-presenting cells, forming an MR1:A6FP complex that fails to activate MAIT cell TCR, thereby acting as a competitive inhibitor of MAIT cell activation. Acetyl-6-formylpterin exacerbates house dust mite-induced airway hyperresponsiveness and elevates circulating IgE levels. Acetyl-6-formylpterin reduces systemic MAIT cell activity and decreases the frequency of IL-17A + and IFNγ + MAIT cells in the spleen. Acetyl-6-formylpterin is useful for the study of allergic asthma .
Cat. No.: HY-P0277
CAS No.: 168635-85-6
Synonyms: CEA peptide
Cat. No.: HY-P99266
CAS No.: 652153-01-0
Synonyms: Anti-Human CD4 Recombinant Antibody
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Cat. No.: HY-163372
CAS No.: 3034182-97-0
PROTAC HPK1 Degrader-1 (compound B1) is a PROTAC degrader that recruits cereblon to induce HPK1 degradation, with a DC50 of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits HPK1 kinase activity, with an IC50 of 140.5 nM. PROTAC HPK1 Degrader-1 suppresses the phosphorylation of SLP76 protein, with an IC50 of 496.1 nM. PROTAC HPK1 Degrader-1 can be used to investigate non-kinase-dependent signaling of HPK1 in the TCR pathway and cancer-related research .
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KRM-III is an orally active TCR inhibitor and NFAT inhibitor with an IC50 of 5 μM against NFAT. KRM-III has no effect on the activation of NF-κB. KRM-III inhibits T cell proliferation induced by T cell antigen receptor stimulation. KRM-III abrogates anti-CD3 antibody-induced cell activation in vivo. KRM-III reduces paw pad swelling in delayed-type hypersensitivity induced by Bovine serum albumin (HY-D0842). KRM-III alleviates the severity of experimental autoimmune encephalomyelitis (EAE) in mice. KRM-III can be used in studies related to experimental autoimmune encephalomyelitis .
Cat. No.: HY-P990303
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Cat. No.: HY-P99146
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Infection Neurological Disease Inflammation/Immunology Cancer
Cat. No.: HY-P1822
CAS No.: 329696-49-3
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Cat. No.: HY-P0287
CAS No.: 159646-83-0
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Cat. No.: HY-P10581A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
