Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
242 Results for "
splicing
" in MedChemExpress (MCE) Product Catalog:
Products (242)
242 Results for "splicing" in MCE Product Catalog:
Cat. No.: HY-13650R
CAS No.: 165668-41-7
Synonyms: E 7070 (Standard)
Research Areas:
Indisulam (Standard) (E 7070 (Standard)) is the analytical standard of Indisulam (HY-13650). This product is intended for research and analytical applications. Indisulam (E 7070) is a carbonic anhydrase inhibitor and RBM39 molecular glue degrader, with Ki values of 31, 15, and 24 nM against human carbonic anhydrase I, II, and IX, respectively, and a Ki value of 65 nM against bovine carbonic anhydrase IV. Indisulam promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase complex, triggering polyubiquitination and proteasomal degradation of RBM39. Indisulam induces aberrant pre-mRNA splicing, G1 cell cycle arrest, and cell death in cancer cells. As an anticancer agent, Indisulam drives tumor regression and growth inhibition in xenograft models. Indisulam can be used in research related to solid tumors, hematologic and lymphoid malignancies, colorectal cancer, and non-small cell lung cancer .
Cat. No.: HY-145425
CAS No.: 2771006-54-1
Research Areas:
PAIR2 is a highly selective inhibitor targeting the kinase domain of human IRE1α, with a Ki value of 8.8 nM against human IRE1α. PAIR2 fully occupies the ATP-binding site of the IRE1α kinase domain, partially antagonizes the ribonuclease activity of IRE1α, specifically inhibits regulated IRE1α-dependent decay (RIDD) and its mediated substrate cleavage, while preserving the splicing function of Xbp1 mRNA. PAIR2 also promotes the differentiation of B cells into plasma cells, blocks IRE1α-induced cell apoptosis, and restores the expression of Fgfr2 mRNA in AT2 cells. PAIR2 effectively reaches a steady-state concentration in the lung tissues of Mus musculus, and serves as an important tool for investigating the function of the IRE1α signaling pathway in diseases such as pulmonary fibrosis .
Cat. No.: HY-P11698
CAS No.: 476667-31-9
Research Areas:
Cat. No.: HY-P7692
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: C1QBP; splicing Factor SF2-Associated Protein; Prev. HABP1; ASF/SF2-Associated Protein P32; Complement Component 1 Q Subcomponent-Binding Protein, Mitochondrial; Glycoprotein GC1qBP; Mitochondrial Matrix Protein P32; SF2AP32; Hyaluronan-Binding Protein 1
Species:
Human
Source:
E. coli
Cat. No.: HY-P72517
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB5; Leukocyte Immunoglobulin-Like Receptor 8; Leukocyte Immunoglobulin Like Receptor B5; CD85 Antigen-Like Family Member C; LIR-8; Leucocyte Ig-Like Receptor B5; LIR8; Leukocyte Immunoglobulin Like Receptor B5 Short splicing Isoform; CD85c; Leukocyte
Species:
Human
Source:
HEK293
Cat. No.: HY-P77443
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB5; Leukocyte Immunoglobulin-Like Receptor 8; Leukocyte Immunoglobulin Like Receptor B5; CD85 Antigen-Like Family Member C; LIR-8; Leucocyte Ig-Like Receptor B5; LIR8; Leukocyte Immunoglobulin Like Receptor B5 Short splicing Isoform; CD85c; Leukocyte
Species:
Human
Source:
HEK293
Cat. No.: HY-P78485
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LILRB5; Leukocyte Immunoglobulin-Like Receptor 8; Leukocyte Immunoglobulin Like Receptor B5; CD85 Antigen-Like Family Member C; LIR-8; Leucocyte Ig-Like Receptor B5; LIR8; Leukocyte Immunoglobulin Like Receptor B5 Short splicing Isoform; CD85c; Leukocyte
Species:
Human
Source:
HEK293
Cat. No.: HY-P78839
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB5; Leukocyte Immunoglobulin-Like Receptor 8; Leukocyte Immunoglobulin Like Receptor B5; CD85 Antigen-Like Family Member C; LIR-8; Leucocyte Ig-Like Receptor B5; LIR8; Leukocyte Immunoglobulin Like Receptor B5 Short splicing Isoform; CD85c; Leukocyte
Species:
Human
Source:
HEK293
Cat. No.: HY-P700781
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB5; Leukocyte Immunoglobulin-Like Receptor 8; Leukocyte Immunoglobulin Like Receptor B5; CD85 Antigen-Like Family Member C; LIR-8; Leucocyte Ig-Like Receptor B5; LIR8; Leukocyte Immunoglobulin Like Receptor B5 Short splicing Isoform; CD85c; Leukocyte
Species:
Human
Source:
HEK293
Cat. No.: HY-P704529
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK5; Cyclin-Dependent Kinase 5; Cyclin Dependent Kinase 5; TPKII Catalytic Subunit; PSSALRE; Epididymis Secretory Sperm Binding Protein; Serine/Threonine-Protein Kinase PSSALRE; Protein Kinase CDK5 splicing; Tau Protein Kinase II Catalytic Subunit; CDKN5; Cell Division Protein Kinase 5; LIS7; Cyclin-Dependent-Like Kinase 5
Species:
Human
Source:
E. coli
Cat. No.: HY-P85533
Synonyms: Cdk 5; Cdk5; CDK5_HUMAN; Cell division protein kinase 5; Crk6; Cyclin dependent kinase 5; Cyclin-dependent kinase 5; Protein kinase CDK5 splicing; PSSALRE; Serine threonine protein kinase PSSALRE; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit.
Cat. No.: HY-P72056
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TRA2B; TRA-2 Beta; Prev. SFRS10; Transformer 2 Beta Homolog (Drosophila); Htra2-Beta; HTRA2-Beta; PPP1R156; TRA2-BETA; splicing Factor, Arginine/Serine-Rich 10 (Transformer 2 Homolog, Drosophila); TRA2-Beta; Protein Phosphatase 1, Regulatory Subunit 156;
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P72298
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK5; Cyclin-Dependent Kinase 5; Cyclin Dependent Kinase 5; TPKII Catalytic Subunit; PSSALRE; Epididymis Secretory Sperm Binding Protein; Serine/Threonine-Protein Kinase PSSALRE; Protein Kinase CDK5 splicing; Tau Protein Kinase II Catalytic Subunit; CDKN5; Cell Division Protein Kinase 5; LIS7; Cyclin-Dependent-Like Kinase 5
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P705886
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SRPK1; Serine/Arginine-Rich splicing Factor Kinase 1; SRSF Protein Kinase 1; SR-Protein-Specific Kinase 1; SFRS Protein Kinase 1; Non-Specific Serine/Threonine Protein Kinase; SFRSK1; Serine/Threonine-Protein Kinase SRPK1; Serine/Arginine-Rich Protein-Specific Kinase 1; SR Protein Kinase 1
Species:
Human
Source:
E. coli
Cat. No.: HY-P703295
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: U2AF2; U2AF65; U2 SnRNP Auxiliary Factor Large Subunit; U2 Small Nuclear RNA Auxiliary Factor 2; splicing factor U2AF 65 kDa subunit; U2 auxiliary factor 65 kDa subunit; hU2AF65; hU2AF65; U2 snRNP auxiliary factor large subunit; DEVDFB; HU2AF(65); Splicin
Species:
Human
Source:
E. coli
Cat. No.: HY-P705437
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPARG; PPARG5; Peroxisome Proliferator Activated Receptor Gamma; Peroxisome Proliferator-Activated Receptor-Gamma splicing; NR1C3; Peroxisome Proliferative Activated Receptor, Gamma; Peroxisome Proliferator-Activated Receptor Gamma; Peroxisome Proliferator-Activated Receptor-Gamma 5; Nuclear Receptor Subfamily 1 Group C Member 3; PPAR Gamma; PPAR-Gamma; PPARG2D5; PPARgamma; FPLD3; PPARG2; CIMT1; PPARG1; GLM1
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P87087
Synonyms: Serine/arginine rich protein specific kinase 1 antibody; Serine/arginine rich splicing factor kinase 1 antibody; Serine/arginine-rich protein-specific kinase 1 antibody; Serine/threonine protein kinase SRPK1 antibody; Serine/threonine-protein kinase SRPK1 antibody; SFRS protein kinase 1 antibody; SFRSK1 antibody; SR protein kinase 1 antibody; SR protein specific kinase 1 antibody; SR-protein-specific kinase 1 antibody; Serine/arginine rich protein specific kinase 1 antibody; Serine/arginine rich splicing factor kinase 1 antibody; Serine/arginine-rich protein-specific kinase 1 antibody; Serine/threonine protein kinase SRPK1 antibody; Serine/threonine-protein kinase SRPK1 antibody; SFRS protein kinase 1 antibody; SFRSK1 antibody; SR protein kinase 1 antibody; SR protein specific kinase 1 antibody; SR-protein-specific kinase 1 antibody; SRPK1 antibody; SRPK1_HUMAN antibody;
Cat. No.: HY-L248
858 compounds
The RNA-targeted bioactive compound library is a high-quality collection of small molecules specifically designed and curated to target RNA structures and functions. It is widely applied in cutting-edge drug discovery and life science research. Unlike traditional strategies that focus on protein targets, RNA-targeted compounds can directly modulate various functional RNA molecules by influencing their splicing, translation, stability, or structural conformation, thereby enabling precise intervention in key biological processes. In the field of drug development, these compounds provide a novel approach to addressing previously “undruggable” targets and have demonstrated significant potential in areas such as oncology, antiviral therapies, and neurodegenerative diseases. For example, by targeting disease-associated RNA structural domains or regulating the aberrant expression of non-coding RNAs, these compounds can effectively inhibit disease progression or restore normal cellular function. In mechanistic studies, RNA-targeted compounds serve as valuable chemical biology tools to elucidate the roles of RNA in gene expression regulation, cellular signaling pathways, and disease development.
The MCE RNA-targeted bioactive compound library contains 858 compounds, sourced from databases such as TargetRX Atlas and R-BIND. The library features excellent structural diversity and biological activity, making it suitable for high-throughput screening (HTS), target validation, phenotypic screening, and lead compound discovery. It represents a valuable resource for RNA-related research and innovative drug development.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
