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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
238 Results for "
fluorogenicity
" in MedChemExpress (MCE) Product Catalog:
Products (238)
238 Results for "fluorogenicity" in MCE Product Catalog:
Cat. No.: HY-P3120A
CAS No.: 2237216-67-8
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Synonyms: DBF
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4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorogenic substrate for β-glucosidase, utilizes to assay β-glucosidase activity . 4-Methylumbelliferyl β-D-Glucopyranoside releases the highly fluorescent 4-methylumbelliferyl (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively .
Synonyms: 4-MUB
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4-Methylumbelliferyl butyrate (4-MUB) is a fluorogenic esterase substrate that is hydrolyzed by esterases to release the fluorescent product 4-methylumbelliferone (HY-N0187). 4-Methylumbelliferyl butyrate is hydrolyzed by the general esterases (GE) of Daphnia magna and Chironomus riparius; it also serves as a substrate for the recombinant mycobacterial carboxylesterase MT2282 (CaeA). 4-Methylumbelliferyl butyrate is used to determine the activity of the S. aureus serine hydrolases FphB and FphH. 4-Methylumbelliferyl butyrate is used in studies related to esterase activity assays .
Cat. No.: HY-D1506
CAS No.: 1407523-31-2
Cat. No.: HY-P5272
CAS No.: 112844-49-2
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Cat. No.: HY-W654272
CAS No.: 2181774-46-7
Synonyms: 4-MU-α-idoa 2-sulfate sodium
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4-Methylumbelliferyl-α-L-iduronide 2-sulfate (4-MU-α-idoa 2-sulfate) sodium is a fluorogenic substrate of iduronate-2-sulfatase (I2S). 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium can be hydrolyzed by lysosomal enzyme α-l-iduronidase (IDUA) and release the fluorophore 4-Methylumbelliferone (HY-N0187). 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium can be used to detect Hurler syndrome .
Cat. No.: HY-P5415
CAS No.: 127134-13-8
Cat. No.: HY-D1632
CAS No.: 460085-45-4
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4-MU-α-GlcNS sodium is a fluorogenic substrate for heparan sulfate sulfamidase, with apparent Km values of 4 mM and 8 mM for fibroblast and leukocyte enzymes, respectively. 4-MU-α-GlcNS sodium undergoes enzymatic desulfation to generate an intermediate, which requires a second incubation with yeast α-glucosidase to hydrolyze and release 4-methylumbelliferone, detected by fluorescence at Ex/Em = 365/450 nm. 4-MU-α-GlcNS sodium is suitable for fibroblast homogenates, leukocytes, and dried leukocyte filter paper samples, and can be used for the detection and study of enzyme activity in mucopolysaccharidosis type IIIA .
Cat. No.: HY-D3445
CAS No.: 3029700-80-6
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JF629-HTL is a far-red fluorogenic HaloTag ligand. Binding of JF629-HTL to HaloTag protein alters the local environment of the dye, promoting the transition of rhodamine from a non-fluorescent state to a fluorescent state, thereby generating a fluorescence enhancement signal. In the light-controlled psHaloTag system, JF629-HTL shows a 6.7-fold fluorescence enhancement after irradiation at 450 nm. JF629-HTL serves as a research tool for far-red fluorescence imaging and the development of chemogenetic biosensors .
Cat. No.: HY-131026
Synonyms: JF635, SE; JF635, NHS
Cat. No.: HY-D3361
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JF639-HTL is a deep-red fluorescent dye belonging to the Janelia Fluor series and also a HaloTag ligand. JF639-HTL contains a methoxy group as the R substituent, which forms a specific covalent bond with HaloTag fusion proteins. JF639-HTL is fluorogenic, exhibiting low background fluorescence in solution and a significant fluorescence enhancement upon binding to proteins. It also possesses cell permeability and excellent photostability. JF639-HTL can be used in studies related to fluorescent labeling, localization tracking, and pulse-chase imaging of proteins in living cells .
Cat. No.: HY-131028
Purity: ≥95.0%
Synonyms: JF646 TFA
Cat. No.: HY-W016288R
CAS No.: 7149-49-7
Synonyms: 2,3-Naphthalenedicarboxaldehyde (Standard); Naphthalene-2,3-dialdehyde (Standard)
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Naphthalene-2,3-dicarboxaldehyde (Standard) is the analytical standard for Naphthalene-2,3-dicarboxaldehyde (HY-W016288). This product is for research and analytical applications. Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candida albicans aspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candida albicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis .
Cat. No.: HY-N15826
CAS No.: 3077081-47-8
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RBM1-151, a 1-deoxy derivative and vinilog of RBM14-C12 (HY-150163), as a fluorogenic substrate of Amidases (HY-P2736) (Ex/Em). RBM1-151 is hydrolyzed by acid ceramidase (AC) (( appKm = 7.0 μM; appVmax = 99.3 nM/min), N-acylethanolamine-hydrolyzing acid amidase ( appKm = 0.73 μM; appVmax = 0.24 nM/min), and fatty Acid amide hydrolase (FAAH) ( appKm = 3.6 μM; appVmax = 7.6 nM/min) but not by other ceramidases. RBM1-151 is applicable for basic biological studies of lipid amidase function, as well as potential diagnostic/prognostic evaluations of diseases involving dysregulated AC, NAAA, or FAAH (Farber disease, cancer) .
Cat. No.: HY-131027
Purity: 99.87%
Synonyms: JF646, Azide
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
