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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
298 Results for "
STING
" in MedChemExpress (MCE) Product Catalog:
Products (298)
298 Results for "STING" in MCE Product Catalog:
Cat. No.: HY-12885C
Purity: 98.94%
Synonyms: ADU-S100 enantiomer ammonium salt; MIW815 enantiomer ammonium salt; ML RR-S2 CDA enantiomer ammonium salt
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2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (ADU-S100 enantiomer ammonium salt) is the less active enantiomer of 2’3’-c-di-AM(PS)2 (Rp,Rp). 2’3’-c-di-AM(PS)2 (Rp,Rp) is an activator of stimulator of interferon genes (STING) .
Cat. No.: HY-149724
CAS No.: 3035442-58-8
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Anti-inflammatory agent 65 (compound 29) is a Hederagonic acid derivative with potent anti-inflammatory activity. Anti-inflammatory agent 65 inhibits nitric oxide (NO) release. Anti-inflammatory agent 65 inhibits the nuclear translocation of IRF3 and p65, and disrupts the STING/IRF3/NF-κB signaling pathway, thereby attenuating the inflammatory response .
Cat. No.: HY-160225F
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Biotin-labeled ISD sodium is a biotin-labeled form of ISD sodium (HY-160225). ISD sodium is an interferon-stimulatory DNA, a 45 bp non-CpG double-stranded oligonucleotide derived from the Listeria monocytogenes genome. ISD sodium can potently induce type I interferon production via the cGAS‑STING‑TBK1‑IRF3 pathway .
Cat. No.: HY-175472
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(GalNAc)3-CPT is a glycoconjugate prodrug that targets the asialoglyco-protein receptor (ASGR) overexpressed on hepatocytes. (GalNAc)3-CPT exhibits significant antitumor activity (IC50 value of 3.07 μM in HepG2 cells) by activating the cGAS-STING pathway and promoting CD8+ T cell infiltration into tumors, thereby inducing tumor cell apoptosis .
Cat. No.: HY-176296
CAS No.: 2687222-58-6
Synonyms: SR-8541A
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Vizenpistat (SR-8541A) is an orally active ENPP1 inhibitor. Vizenpistat increases cGAMP levels, blocks 2′3′-cGAMP hydrolysis, inhibits adenosine production, regulates innate immune signaling mediated by the STING pathway, and modulates anti-tumor immune responses. Vizenpistat is applicable to research related to breast cancer and metastatic microsatellite-stable colorectal cancer .
Cat. No.: HY-12512R
CAS No.: 849214-04-6
Synonyms: Cyclic GMP-AMP (Standard); 3',3'-cGAMP (Standard)
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cGAMP (Standard) is the analytical standard of cGAMP (HY-12512). This product is intended for research and analytical applications. cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
Cat. No.: HY-N15159
CAS No.: 146776-30-9
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Cat. No.: HY-107780
CAS No.: 61093-23-0
Synonyms: c-di-GMP; cyclic diguanylate; 5GP-5GP
Category:
Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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Cat. No.: HY-107780A
Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium
Category:
Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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Cat. No.: HY-13735H
CAS No.: 78901-94-7
Synonyms: Acriquine acetate
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Quinacrine (Acriquine) acetate is a small molecule modulator of the cGAS-STING-TBK1 signaling pathway, possessing immune stimulatory activity. Quinacrine acetate has been explored for its potential therapeutic applications in enhancing anti-tumor immunity. Quinacrine acetate can improve the effectiveness of cancer immunotherapies by addressing the poor immunogenicity of various tumors. Quinacrine acetate also presents a promising strategy for overcoming the limitations associated with immune checkpoint inhibitors in cancer treatment.
PROTAC PARP1 degrader-1 is a PARP1 PROTAC degrader with a DC50 value of 252.5 nM. PROTAC PARP1 degrader-1, combined with Daunorubicin (HY-13062A), induces the accumulation of cytoplasmic DNA fragments, activates the cGAS/STING innate immune pathway, and remodels the tumor microenvironment. PROTAC PARP1 degrader-1 can be used in research related to breast cancer .
Cat. No.: HY-164288
CAS No.: 2287331-29-5
Synonyms: TDI-006570
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TDI-6570 (TDI-006570) is a blood-brain barrier-permeable, orally active cGAS inhibitor with an IC50 of 1.64 μM. TDI-6570 exhibits high gastrointestinal absorption and a long brain half-life in mice, and shows no toxicity to primary neurons. By inhibiting the cGAS-STING-IFN signaling pathway, TDI-6570 reduces STING levels and the activation of TBK1, blocks double-stranded DNA-induced cGAS activation and downstream interferon-stimulated gene expression, thereby reducing tau protein spread and improving synaptic loss. TDI-6570 reverses memory deficits, increases the amplitude of long-term potentiation, enhances the MEF2C transcriptional network, restores PSD-95 and vGAT punctate structures, and significantly improves cognitive resilience. TDI-6570 can be applied to the research of Alzheimer's disease, Parkinson's disease, systemic lupus erythematosus, as well as various central nervous system and autoimmune diseases .
Cat. No.: HY-139678
CAS No.: 2839142-69-5
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SC13 is an orally active, selective Flap structure-specific endonuclease 1 (FEN1) inhibitor and mu opioid receptor (MOR) activator. SC13 impairs DNA damage repair and induces apoptosis in cancer cells. SC13 activates cGAS-STING signaling, increases chemokine secretion, and promotes CAR-T cell infiltration at solid tumour sites. SC13 can be used for the research of solid tumours and pain .
Cat. No.: HY-189632
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YS3074 is a selective ENPP1 inhibitor with an IC50 of 4.23 nM. YS3074 inhibits ENPP1-mediated hydrolysis of extracellular cGAMP, thereby preserving cGAMP to activate the STING signaling pathway. YS3074 exhibits antitumor effects both as a single agent and in combination with anti-PD-1 antibodies, enhancing tumor growth inhibition and prolonging survival. YS3074 can be used for research on colorectal cancer .
Cat. No.: HY-100564AR
CAS No.: 2734858-36-5
Synonyms: 2'-3'-cyclic GMP-AMP sodium (Standard)
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Cat. No.: HY-100564R
CAS No.: 1441190-66-4
Synonyms: 2'-3'-cyclic GMP-AMP (Standard)
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Cat. No.: HY-12885AR
CAS No.: 1638750-95-4
Synonyms: ADU-S100 disodium salt (Standard); MIW815 disodium salt (Standard); ML RR-S2 CDA disodium salt (Standard)
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2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (Standard) is the analytical standard of 2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (HY-12885A). This product is intended for research and analytical applications. 2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).
Cat. No.: HY-141662
CAS No.: 2586047-11-0
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2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases .
Cat. No.: HY-159146
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PPARα agonist 4 (compound BH400) is a PPARα agonist (EC50= 1.2 μM). PPARα agonist 4 also inhibits STING (IC50: 8.1 μM). PPARα agonist 4 reduces the CoCl2-induced production of ROS and LPS-induced secretion of IL-6. The PPARα agonist 4 restores the decreased expression of PCG1α induced by LPS .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
