283 Results for "

T-3

" in MedChemExpress (MCE) Product Catalog:
Products (283)

283 Results for "T-3" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-N6583
CAS No.: 60197-60-6
Licoflavonol, a minor flavone from the roots of Glycyrrhiza uralensis, is an inhibitor of the Salmonella type III secretion system (T3SS) .
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2
2 Cited Publications
Cat. No.: HY-100449
CAS No.: 246246-19-5
Purity:  99.00%
AL-8810 is a potent and selective antagonist of the PGF 2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The Ki of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG) [3] .
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1
1 Cited Publications
Cat. No.: HY-D0896
CAS No.: 82-76-8
Synonyms: ANSA; 8-Anilino-1-naphthalenesulfonic acid
ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor targeting thyroxine binding globulin (TBG) (Ki=2.09×10 6 M -1). ANS is used in radioimmunoassay by displacing bound triiodothyronine (T3) to improve detection sensitivity. ANS can block the protein binding site of T3 and release free T3 for antibody recognition. As a fluorescent probe, ANS can specifically bind to the hydrophobic region of proteins (such as membrane proteins) and monitor the dynamics of protein conformation through changes in fluorescent signals. It is widely used in biochemical research and antibacterial material development .
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1
1 Cited Publications
Cat. No.: HY-112624I
CAS No.: 9004-54-0
Synonyms: Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance [3].
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1 Cited Publications
Cat. No.: HY-W008859
CAS No.: 67-30-1
Synonyms: Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities .
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1
1 Cited Publications
Cat. No.: HY-A0070AG
CAS No.: 6893-02-3
Synonyms: Triiodothyronine (GMP); 3,3',5-Triiodo-L-thyronine (GMP); T3 (GMP)
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively .
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1
1 Cited Publications
Cat. No.: HY-148859
CAS No.: 2938207-23-7
Purity:  ≥98.0%
Target:  

Liposome

AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts .
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1
1 Cited Publications
Cat. No.: HY-110094
CAS No.: 134296-40-5
Purity:  99.60%
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors .
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1
1 Cited Publications
Cat. No.: HY-P86804
Synonyms: 4930549J05Rik antibody; A430104F18Rik antibody; AW552088 antibody; Cd247 antibody; CD3 antibody; CD3 delta antibody; CD3 epsilon antibody; CD3 eta antibody; CD3 gamma antibody; CD3 zeta antibody; CD3H antibody; CD3Q antibody; CD3Z antibody; CD3zeta antibody; Ctg3 antibody; FLJ17620 antibody; FLJ17664 antibody; FLJ18683 antibody; FLJ79544 antibody FLJ94613 antibody; IMD19 antibody; Leu-4 antibody; MGC138597 antibody; OKT3, delta chain antibody; OTTHUMP00000032544 antibody; T cell receptor antibody; T3 antibody; T3d antibody; T3e antibody; T3g antibody; T3z antibody; TCRE antibody; TCRk antibody; Tcrz antibody; TCRzeta antibody

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, IF-Tissue, mIHC

Reactivity:  

Human

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1
1 Cited Publications
Cat. No.: HY-P80598
Synonyms: CD3E; T3E; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e

Host:  

Rabbit

Application:  

WB, IHC-P, IP

Reactivity:  

Human

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1
1 Cited Publications
Cat. No.: HY-156010
CAS No.: 2682078-97-1
Purity:  99.57%
Target:  

PPAR

Research Areas:  

Metabolic Disease

PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. PPARγ-IN-2 inhibits TG accumulation in 3T3-L1 preadipocytes (EC50: 0.106 μM). PPARγ-IN-2 inhibits high-cholesterol diet (HFC)-induced obesity and related metabolic syndrome, and reduces lipid accumulation in adipose tissue .
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1
1 Cited Publications
Cat. No.: HY-145446
CAS No.: 1997319-84-2
Purity:  99.84%
Target:  

SWI/SNF Complex

Research Areas:  

Metabolic Disease

SGC-SMARCA-BRDVIII, a chemical probe, is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts .
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1
1 Cited Publications
Cat. No.: HY-N0704
CAS No.: 55576-66-4
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 [3].
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1 Cited Publications
Cat. No.: HY-116538
CAS No.: 2420-56-6
Purity:  99.10%
Synonyms: trans-10,cis-12 CLA2
(10E,12Z)-Octadeca-10,12-dienoic acid (trans-10,cis-12 CLA2) is an orally active PPARα activator and inhibits adipocyte differentiation. (10E,12Z)-Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z)-Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. (10E,12Z)-Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. (10E,12Z)-Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. (10E,12Z)-Octadeca-10,12-dienoic acid can reduce lipoprotein lipase (LPL) activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. (10E,12Z)-Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. (10E,12Z)-Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-κB and Cyclin D1 protein levels in mice [3] .
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Cat. No.: HY-107903
CAS No.: 9010-34-8
Purity:  93%
Synonyms: Thyroglobulin from bovine
Research Areas:  

Cancer

Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle. Thyroglobulin activates Akt kinase activity in FRTL-5 thyroid cell .
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Cat. No.: HY-B1770
CAS No.: 7681-82-5
Sodium Iodide is a compound composed of sodium ions and iodine ions. Sodium Iodide scavenges hydrogen peroxide. Sodium Iodide maintains the level of thyroid hormone T3 through its iodine component. Sodium Iodide protects tissues from oxidative damage and regulates thyroid homeostasis. Sodium Iodide relieves acute myocardial infarction [3].
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Cat. No.: HY-B1234
CAS No.: 5466-77-3
Synonyms: Octyl methoxycinnamate
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo [3] .
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Cat. No.: HY-A0070AR
CAS No.: 6893-02-3
Synonyms: Triiodothyronine (Standard); 3,3',5-Triiodo-L-thyronine (Standard); T3 (Standard)
Liothyronine (Standard) is the analytical standard of Liothyronine. This product is intended for research and analytical applications. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively [3].
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Cat. No.: HY-126996
CAS No.: 31135-55-4
Purity:  ≥98.0%
Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity .
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Cat. No.: HY-18341R
CAS No.: 51-48-9
Synonyms: Levothyroxine (Standard); T4 (Standard)
L-Thyroxine (Standard) is the analytical standard of L-Thyroxine. This product is intended for research and analytical applications. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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