2. AL-8810

AL-8810 is a potent and selective antagonist of the PGF 2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The Ki of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG).

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AL-8810 Chemical Structure

AL-8810 Chemical Structure

CAS No. : 246246-19-5

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AL-8810 Related Antibodies

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Description

AL-8810 is a potent and selective antagonist of the PGF 2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The Ki of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG)[1][2][3][4][5].

In Vitro

AL-8810 (0.1, 1, 10 μM, 24 h) can significantly reduce the neuronal cell death of WT mice after OGD-induced injury[2].
AL-8810 (1, 10 μM, 24 h) promotes the activation of ERK1/2 in HEK 293 and MG-63 cells through epidermal growth factor receptor deactivation mechanism[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AL-8810 Related Antibodies

Western Blot Analysis[3]

Cell Line: HEK 293, MG-63
Concentration: 1, 10 μM
Incubation Time: 24 h
Result: Activated ERK1/2 and MAPK.
Activated MAPK through EGFR transactivation.
In Vivo

AL-8810 (1 or 10 mg/kg, intravenously) reduces ischemic brain injury and neurotoxicity in mice[2].
AL-8810 (10 mg/kg, intraperitoneal injection) can improve the prognosis after experimental traumatic brain injury in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Stroke mouse model[2]
Dosage: 1 or 10 mg/kg
Administration: i.v.
Result: Reduced the cortical infarct volume and tape-removal times.
Animal Model: Traumatic brain injury (TBI) model[5]
Dosage: 10 mg/kg
Administration: i.p.
Result: Improved neurological deficit scores (NDS) at 24 and 48 hours after controlled cortical impact (CCI).
Molecular Weight

402.50

Formula

C24H31FO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](C2CC3=C(C=CC=C3)C2)O)[C@@H](F)C[C@@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-8810246246-19-5AL8810AL 8810Inhibitorinhibitorinhibit

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